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Background Fetuin-A is a multifunctional hepatic secretory protein that is involved in the pathology of many disorders. Recent epidemiological studies showed that serum Fetuin-A was associated with insulin resistance and its comorbidities, such as metabolic syndrome and type 2 diabetes. Hyperthyroidism involves a significant increase in the level of tissue metabolism and is often accompanied by abnormal glucose tolerance and insulin resistance. Aim The aim of this work is to study the relationship between serum Fetuin-A and insulin resistance in patients with hyperthyroidism. Participants and methods Our study was carried out on 35 newly diagnosed patients with hyperthyroidism (group I) and 20 healthy individuals matched for age and sex as controls (group II). Fetuin-A, fasting insulin, fasting blood glucose, free T3, free T4, thyroid stimulating hormone, total serum calcium, and high-sensitivity C-reactive protein were measured before and after euthyroidism was established. Results Significantly higher levels of serum Fetuin-A were noted in the patient group before treatment compared with the control group. There was a significant decrease in serum Fetuin-A in the patients after treatment in comparison with before treatment. There was an insignificant difference between the patients after treatment and the control group in terms of serum Fetuin-A. Fetuin-A was correlated positively with Homeostasis Model of Assessment-Insulin Resistance, High-sensitivity C-reactive protein, fT3, and fT4, whereas there was a negative correlation between thyroid stimulating hormone and Fetuin-A. Conclusion This study provides direct evidence for a relationship between serum Fetuin-A and insulin resistance in patients with hyperthyroidism.

Background Helicobacter pylori is a pathogenic bacterium that has been linked to many disorders such as cardiovascular diseases, diabetes mellitus, and dyslipidemia. However, whether it is associated with insulin resistance still needs to be evaluated. In this work we aimed to delineate the possible relation of H. pylori infection with insulin resistance in nonobese nondiabetic patients. Patients and methods The study was carried out on 80 individuals who were divided into two groups. Forty patients were diagnosed to have H. pylori and 40 healthy volunteers formed the control group. All were subjected to history taking, clinical examination, routine laboratory investigations, evaluation of H. pylori immunoglobulin G level, and assessment of fasting blood glucose and fasting insulin level to calculate homeostasis model assessment of insulin resistance. Results There was a significant increase in C-reactive protein in H. pylori-positive patients when compared with H. pylori-negative controls. Also a significant positive correlation was found between homeostasis model assessment of insulin resistance and each of fasting blood glucose, fasting insulin, and C-reactive protein in both groups. Conclusion H. pylori infection was strongly associated with insulin resistance in nonobese, nondiabetic patients.