This paper describes women's roles in the processes of territory construction and the Colombian Caribbean coast regionalization. First, we present women participation in the adaptation of the first inhabitants, through their contribution to creating the most important cultures that emerged in that region, such as Tairona and Sinu. This paper also considers native women's resistance actions against Spanish invasion; women participation in African, native, mestizo, zambo, mad criollo freeing fights against colonialism and ha the consolidation of the Republic; along with their contribution to building the social fabric that consolidated the social life of new born towns and cities; which transformed women into family group integrators, new generation socializing forces, and sponsors of the family structure performance. The second line of argument addressed in this article refers to women involvement in the regionalization of the Colombian Caribbean, by establishing and concluding that, although regionalization has happened, the recognition of its practical and strategic interests has not been guaranteed to allow changes in the social, economic, and political position. The reason is that, even though such interests were expressed in some forums held to reach an agreement on the vision and the requirements of the region, the social movement has not had any access to decision making, though this has not prevented its gaining strength in the last decades. [ABSTRACT FROM AUTHOR]