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We consider marginal generalized partially linear single-index models for longitudinal data. A profile generalized estimating equations (GEE)-based approach is proposed to estimate unknown regression parameters. Within a wide range of bandwidths for estimating the nonparametric function, our profile GEE estimator is consistent and asymptotically normal even if the covariance structure is misspecified. Moreover, if the covariance structure is correctly specified, the semiparametric efficiency can be achieved under heteroscedasticity and without distributional assumptions on the covariates. Simulation studies are conducted to evaluate the finite sample performance of the proposed procedure. The proposed methodology is further illustrated through a data analysis. [ABSTRACT FROM AUTHOR]