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1. Chiral trans-carboxylic trifluoromethyl 2-imidazolines by a Ag2O-catalyzed Mannich-type reaction.

Author

Trulli, Laura, Sciubba, Fabio, and Fioravanti, Stefania

Subjects
*TRIFLUOROMETHYL compounds, *IMIDAZOLINES, *ALDIMINES, *ESTERS, *RING formation (Chemistry), *ORGANOCATALYSIS, *STEREOSELECTIVE reactions
Abstract

Trifluoromethyl aldimines derived from α-amino esters have proven to be very good starting materials to obtain the title compounds. A Ag 2 O-catalyzed Mannich-type/cyclization cascade reaction starting from suitable α-isocyano acetates leads to enantiopure valuable trans -carboxylic trifluoromethyl substituted 2-imidazolines by a highly stereoselective addition without the need to add organocatalysts. [ABSTRACT FROM AUTHOR]

Published
2018
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