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Your search keyword '"Sabino, José R."' showing total 1 results
Start Over Author "Sabino, José R." Publication Year Range Last 10 years Journal tetrahedron letters: international organ for the rapid publication of preliminary communications in organic chemistry
1 results on '"Sabino, José R."'

1. A simple one-pot methodology for the synthesis of substituted benzoylguanidines from benzoylthioureas using tert-butyl hydroperoxide.

Author

Esteves, Henrique, de Fátima, Ângelo, Castro, Rosane de P., Sabino, José R., Jr.Macedo, Fernando, and Brito, Tiago Oliveira

Subjects
*GUANIDINES, *BENZOYL compounds, *AMINES, *CRYSTAL structure, *ORGANIC compounds
Abstract

The potential of tert -butyl hydroperoxide as a reagent in the guanylation of benzoylthioureas in the presence of amines has been evaluated in a systematic study involving substrates bearing N 2 -substituents with different electronic properties. The results show that t BuOOH is a suitable and robust reagent for the synthesis of either N 1 , N 2 , N 3 -tri- and tetrasubstituted or N 1 , N 2 -disubstituted guanidines from N 2 -substituted N 1 -benzoylthioureas and N 1 -benzoylthioureas, respectively. The recrystallised guanylation adducts were readily obtained in good yields and at high purity levels after a simple one-pot reaction procedure. The crystal structures of two novel benzoylguanidines are provided. [ABSTRACT FROM AUTHOR]

Published
2015
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