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Your search keyword '"Stewart, W"' showing total 5 results
Start Over Author "Stewart, W" Topic carbocyclic nucleosides Journal tetrahedron letters: international organ for the rapid publication of preliminary communications in organic chemistry
5 results on '"Stewart, W"'

1. A practical synthetic route to 4′-alkylaristeromycin derivatives: 4′-methylaristeromycin

Author

Yin, Xue-qiang and Schneller, Stewart W.

Subjects
*CYCLIC nucleotides, *NUCLEOTIDES, *NUCLEIC acids, *BIOMOLECULES
Abstract

Abstract: (−)-(1S,4R)-4-Hydroxy-2-cyclopenten-1-yl acetate provided a convenient entry point for a 16-step chiral preparation of 4′-methylaristeromycin. This procedure is adaptable to a number of carbocyclic nucleosides with a diversity of substitution at C-4′ and C-5′ and a variety of heterocyclic bases. [Copyright &y& Elsevier]

Published
2006
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2. Isomers of neplanocin A and 2′-deoxyneplanocin A possessing a C-1′/C-6′ double bond

Author

Yin, Xue-qiang and Schneller, Stewart W.

Subjects
*NUCLEAR isomers, *NUCLEOSIDES, *ANTIVIRAL nucleosides, *CYCLOPENTADIENE
Abstract

Abstract: Missing among the unsaturated carbocyclic nucleosides is the 1′,6′-double bond isomer of neplanocin A. A practical synthesis of this compound and its 2′-deoxy derivative is reported from readily accessible cyclopentenols. [Copyright &y& Elsevier]

Published
2005
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3. (+)-Neplanocin F, 2′-fluoroneplanocin, and a 6′-isoneplanocin via a common versatile cyclopentenol precursor

Author

Liu, Chong, Chen, Qi, and Schneller, Stewart W.

Subjects
*ADENOSINES, *TERPENES, *HYDRIDES, *CARBOCYCLIC acids, *CHEMICAL reactions, *NUCLEOSIDES, *CHEMICAL reduction
Abstract

Abstract: Reductive (diisobutylaluminum hydride) ring opening of an acetal protected cyclopentenol has provided a precursor adaptable to uniquely substituted carbocyclic nucleosides. To illustrate the broad implication of this process the preparation of unnatural (+)-neplanocin F, an ara-like 2′-fluoroneplanocin, and a 6′- isomeric l-like neplanocin analog is described. [Copyright &y& Elsevier]

Published
2011
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4. Synthesis of the 6′-iso analogues of neplanocin A and 5′-homoneplanocin A

Author

Ye, Wei, He, Mingzhu, and Schneller, Stewart W.

Subjects
*ADENOSINES, *ORGANIC synthesis, *METATHESIS reactions, *OXIDATION, *NUCLEOSIDES, *CYCLIC compounds
Abstract

Abstract: An efficient synthesis of 6′-isoneplanocin A and 6′-isohomoneplanocin A is reported. The key steps in the synthesis include an enyne metathesis and a regioselective oxidation. [Copyright &y& Elsevier]

Published
2009
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