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Your search keyword '"Augusto Gambacorta"' showing total 3 results
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3 results on '"Augusto Gambacorta"'

1. Amination of α,β-unsaturated (2-trimethylsilanylmethyl) carboxylic esters

Author

M. Antonietta Loreto, Paolo A. Tardella, Tecla Gasperi, Augusto Gambacorta, Gasperi, Tecla, Loreto, M. A., Tardella, P. A., Gambacorta, Augusto, Loreto, M. A, Tardella, P. A, and Gambacorta, A.

Subjects
Trimethylsilyl, Organic Chemistry, Aziridine, Ethyl ester, aziridination, Ring (chemistry), Biochemistry, chemistry.chemical_compound, chemistry, Reductive cleavage, Drug Discovery, ASYMMETRIC SYNTHESES, beta-amino acid, Organic chemistry, (ETHOXYCARBONYL)NITRENE, asymmetric synthese, Amination, After treatment
Abstract

The reactions of (2-trimethylsilanylmethyl) alpha,beta-unsaturated carboxylic ethyl esters with NsONHCO(2)Et and CaO produce, after treatment with AcOH, alpha-methylene N-(ethoxycarbonyl) beta-amino carboxylic esters through ring opening and elimination of the trimethylsilyl group from the intermediate aziridine. By ozonization and subsequent reductive cleavage these products give the corresponding N-(ethoxycarbonyl) beta-amino alpha-hydroxy esters.

Published
2002
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2. A highly regio- and stereoselective C5 oxyfunctionalization of coprostane steroids by dioxiranes: An improved access to progestogen and androgen hormones

Author

Paolo Lupattelli, Augusto Gambacorta, Paolo Bovicelli, Enrico Mincione, Bovicelli, P, Gambacorta, Augusto, Lupattelli, P, and Mincione, E.

Subjects
Progestogen, medicine.drug_class, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Regioselectivity, Androgen, Biochemistry, Steroid, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Organic chemistry, Stereoselectivity, Dimethyldioxirane, Enone, Hormone
Abstract

Coprostane steroids are selectively oxyfunctionalized at C 5 by dimethyldioxirane and methyltrifluoromethyldioxirane to give useful intermediates for bioactive compounds.

Published
1992
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3. Studies related to cephalosporins.IV. Electrophilic addition to 3-exomethylene-1-cephams. The addition of phenylselenenyl chloride

Author

Giampiero Montesperelli, Francesco De Angelis, Rosario Nicoletti, Lorenzo de Ferra, Maurizio Botta, and Augusto Gambacorta

Subjects
Bicyclic molecule, Electrophilic addition, medicine.drug_class, Organic Chemistry, Cephalosporin, Biochemistry, Chloride, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Lactam, Organic chemistry, Derivative (chemistry), medicine.drug
Abstract

Phenylselenenyl chloride addition to the 3-exomethylene-1-cepham 1 gave mainly the seleno derivative 2 at room temperature while the dichloro derivative 3 was obtained in refluxing 1,2-dichloroethane. Compounds 2 and 3 transformed into the Δ2 and Δ3 chloromethyl isomer respectively.

Published
1987
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