1. The synthesis of ethanolamine libraries from olefin scaffolds
- Author
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Craig E. Dixon, Miles Goodman Siegel, Upinder Singh, Stephen W. Kaldor, Paul K. Isbester, Daniel J. Parks, Michael G. Organ, and David J. Lavorato
- Subjects
Olefin fiber ,chemistry.chemical_compound ,Ethanolamine ,Chemistry ,Organic Chemistry ,Drug Discovery ,Ethanolamines ,Sequence (biology) ,Biochemistry ,Combinatorial chemistry - Abstract
A solution-phase, multi-reaction sequence has been developed for the parallel synthesis of ethanolamine libraries. This approach uses 2,3-dibromopropene as a template for the synthesis of a small olefin sub-library, which is then further functionalized to form the final ethanolamine library. The methodology is demonstrated by the synthesis of a 5×4 array of ethanolamines.
- Published
- 2000
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