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Your search keyword '"Michel, Gelbcke"' showing total 4 results
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4 results on '"Michel, Gelbcke"'

1. Synthesis of 15N-labeled vicinal diamines through N-activated chiral aziridines: tools for the NMR study of platinum-based anticancer compounds

Author

Jean Neve, Michel Gelbcke, Michel Luhmer, Emilie Cauet, Gilles Berger, and François Dufrasne

Subjects
chemistry.chemical_classification, Aziridines, Organic Chemistry, Diastereomer, chemistry.chemical_element, Platinum-based anticancer compounds, Ring (chemistry), Biochemistry, Amino acid, Chimie organique, chemistry, Nucleophile, Drug Discovery, Chimie, Organic chemistry, Sciences pharmaceutiques, 15N NMR, Chimie pharmaceutique, Platinum, Chiral diamines, Vicinal
Abstract

A new method for the synthesis of 15N-labeled chiral beta-diamines from a common precursor, either optically pure amino acids or anti-beta-amino alcohols, is reported. The two diastereomeric series of vicinal diamines are produced through the nucleophilic ring opening of activated chiral aziridines. 15N was introduced by means of [15N]-benzylamine, prepared from 15NH4Cl. The final compounds are highly valuable because [1H-15N] NMR is considered a powerful tool for studying the chemical properties of platinum-based complexes., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013
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2. Corrigendum to 'Synthesis of 15N-labeled vicinal diamines through N-activated chiral aziridines: tools for the NMR study of platinum-based anticancer compounds' [Tetrahedron Lett. 54 (2013) 545–548]

Author

François Dufrasne, Michel Luhmer, Michel Gelbcke, Gilles Berger, Jean Neve, and Emilie Cauet

Subjects
Chemistry, Organic Chemistry, Drug Discovery, Polymer chemistry, Tetrahedron, Organic chemistry, chemistry.chemical_element, Platinum, Biochemistry, Vicinal
Published
2015
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