5 results on '"Joseph Sweeny"'
Search Results
2. New Criteria to Identify Patients at Higher Risk for Cardiovascular Complications After Percutaneous Coronary Intervention
- Author
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Alessandro Spirito, Ashutosh Sharma, Davide Cao, Samantha Sartori, Zhongjie Zhang, Johny Nicolas, Carlo Andrea Pivato, Rebecca Cohen, Usman Baber, Joseph Sweeny, Samin K. Sharma, George Dangas, Annapoorna Kini, Sorin J. Brener, and Roxana Mehran
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
A universal definition to identify patients at higher risk of complications after percutaneous coronary intervention (PCI) is lacking. We aimed to validate a recently developed score to identify patients at increased risk of all-cause death after PCI. All consecutive patients from a large PCI registry not presenting with ST-elevation myocardial infarction or cardiogenic shock were included. Each patient was assigned a score obtained by summing the points associated with the following variables: age80 years (3 points), dialysis (6 points), left ventricular ejection fraction30% (2 points), and multivessel PCI (2 points). Patients were stratified in 3 groups: low risk (score 0), intermediate risk (score 2 to 3), or high risk (score ≥4). The primary outcome was all-cause death, and the secondary outcomes were major adverse cardiovascular events and major bleeding. Events were assessed at 1 year after PCI. Between January 2014 and December 2019, 12,689 patients underwent PCI. Compared with the 9,884 patients at low risk, those at intermediate and high risk had a fourfold (hazard ratio 3.99, 95% confidence interval 2.95 to 5.38) and ninefold (hazard ratio 9.55, 95% confidence interval 6.89 to 13.2) higher hazard for all-cause death at 1 year, respectively. The score had a good predictive value for all-cause death at 1 year (area under the curve 0.70). The risk of major adverse cardiovascular events and major bleeding increased consistently from the low- to the high-risk group. In conclusion, in patients who underwent PCI for stable ischemic heart disease or non-ST-elevation acute coronary syndrome, a score based on 4 variables well predicted the risk of all-cause death at 1 year.
- Published
- 2022
3. Impact of High-Density Lipoprotein Levels on Cardiovascular Outcomes of Patients Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents
- Author
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Adam Reisman, Samin K. Sharma, Bimmer E. Claessen, Ridhima Goel, Nitin Barman, Mauro Chiarito, Rebecca Torguson, Johny Nicolas, Rishi Chandiramani, Roxana Mehran, Madhav Sharma, Davide Cao, Dhrubajyoti Bandyopadhyay, Usman Baber, Anastasios Roumeliotis, Samantha Sartori, George Dangas, Annapoorna Kini, and Joseph Sweeny
- Subjects
Male ,Drug ,medicine.medical_specialty ,medicine.medical_treatment ,media_common.quotation_subject ,New York ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,Percutaneous Coronary Intervention ,0302 clinical medicine ,High-density lipoprotein ,Risk Factors ,Internal medicine ,medicine ,Humans ,In patient ,Registries ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,Retrospective Studies ,media_common ,business.industry ,Incidence ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Middle Aged ,Prognosis ,Survival Rate ,surgical procedures, operative ,chemistry ,Conventional PCI ,Cardiology ,Female ,lipids (amino acids, peptides, and proteins) ,Lipoproteins, HDL ,Cardiology and Cardiovascular Medicine ,business ,Cardiovascular outcomes ,Biomarkers ,Follow-Up Studies ,Lipoprotein - Abstract
Low levels of high-density lipoprotein (HDL) have been associated with adverse cardiovascular events in epidemiologic studies. Evidence regarding its role in patients who underwent percutaneous coronary intervention (PCI) is scarce. We evaluated consecutive patients who underwent PCI with drug-eluting stents from 2012 to 2017, excluding those with unavailable baseline HDL, age18 years, presentation with ST-segment elevation myocardial infarction (MI) or shock, and coexisting neoplastic disease. The final population was stratified according to baseline HDL levels into reduced and nonreduced HDL cohorts, with cut-off value 40 mg/dl in males and 50 mg/dl in females. The primary end point was 1-year major adverse cardiovascular events (MACE), defined as the composite of death, MI, or target vessel revascularization (TVR). Among 10,843 patients included, 6,511 (60%) had reduced HDL, and 4,332 (40%) nonreduced HDL. The rate of 1-year MACE was similar between the 2 groups (7.5% vs 6.6%; p = 0.14). Although mortality and MI rates were comparable, reduced HDL was associated with significantly higher TVR 5.2% vs 4.0%; p = 0.02, a finding that attenuated after multivariable adjustment (adjusted hazard ratio 1.18, p = 0.14). Sex subgroup analysis included 7,718 (71.2%) males and 3,125 (28.8%) females. Among men, there was a trend toward higher MACE in those with reduced HDL (7.4% vs 6.0%; p = 0.08) mostly driven by TVR (5.4% vs 3.7%; p = 0.005). No association between HDL and 1-year outcomes was evident in females. Assessment for interaction between sex and reduced HDL did not reach statistical significance. In conclusion, reduced baseline HDL was not associated with increased risk of MACE in a contemporary PCI population.
- Published
- 2020
4. Prognostic Relation Between Severity of Diabetes Mellitus (On or Off Insulin) ± Chronic Kidney Disease with Cardiovascular Risk After Percutaneous Coronary Intervention
- Author
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Annapoorna Kini, Samin K. Sharma, Roxana Mehran, Yuliya Vengrenyuk, Nitin Barman, Samit Bhatheja, Surbhi Chamaria, Hasan Choudhury, Usman Baber, and Joseph Sweeny
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Angina Pectoris ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Humans ,Hypoglycemic Agents ,Insulin ,Medicine ,Angina, Stable ,Angina, Unstable ,030212 general & internal medicine ,Myocardial infarction ,Mortality ,Renal Insufficiency, Chronic ,Non-ST Elevated Myocardial Infarction ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Hazard ratio ,Percutaneous coronary intervention ,Type 2 Diabetes Mellitus ,Middle Aged ,Prognosis ,medicine.disease ,Cardiovascular Diseases ,Conventional PCI ,Cardiology ,ST Elevation Myocardial Infarction ,Female ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease - Abstract
The presence of either diabetes mellitus (DM) or chronic kidney disease (CKD) is associated with a worse prognosis after percutaneous coronary intervention (PCI). It is also known that outcomes in patients treated with insulin (insulin requiring type 2 diabetes mellitus [ITDM]) are worse than those who are not on insulin (non-insulin type 2 diabetes mellitus [NITDM]). We sought to compare long-term outcomes in patients who underwent PCI with varying severity of DM with and without CKD. We retrospectively studied 17,898 patients who underwent PCI from January 2009 to December 2014 in the Mount Sinai Cath Lab. Patients were categorized into groups by the presence or the absence of CKD and by the DM status (none, NITDM, or ITDM). In the absence of CKD, adjusted hazard ratios (95% confidence interval [CI]) for death or myocardial infarction associated with NITDM and ITDM were 1.65 (95% CI 1.02 to 2.67) and 3.78 (95% CI 2.23 to 6.40), respectively. Analogous risks in the presence of CKD were 3.34 (95% CI 1.99 to 5.61) and 6.26 (95% CI 3.84 to 10.2). This study shows that irrespective of renal status, the need for insulin in the setting of DM identifies a group with substantial risk of death or myocardial infarction at 1 year.
- Published
- 2018
5. Temporal Trends in Statin Prescriptions and Residual Cholesterol Risk in Patients With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention
- Author
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Bimmer E. Claessen, Pedro R. Moreno, Usman Baber, Sabato Sorrentino, Rishi Chandiramani, Sherif Elsayed, Ridhima Goel, George Dangas, Samin K. Sharma, Nitin Barman, Annapoorna Kini, Melissa Aquino, Anton Camaj, Joseph Sweeny, Paul Guedeney, Moritz Blum, Roxana Mehran, and Jason C. Kovacic
- Subjects
Male ,medicine.medical_specialty ,Statin ,Time Factors ,medicine.drug_class ,medicine.medical_treatment ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Drug Prescriptions ,Risk Assessment ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Percutaneous Coronary Intervention ,Risk Factors ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Prospective Studies ,Prospective cohort study ,Aged ,business.industry ,Percutaneous coronary intervention ,Odds ratio ,Middle Aged ,medicine.disease ,Cholesterol ,Conventional PCI ,Cardiology ,Female ,Guideline Adherence ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Intensive low-density lipoprotein cholesterol (LDL-C) reduction with statins is recommended after elective percutaneous coronary intervention (PCI). We aimed to evaluate adherence to guideline-recommended statin therapy (GRST) and the rate of residual cholesterol risk (RCR) at follow-up after elective PCI. All patients who underwent elective PCI between January 2010 and May 2016 were prospectively included in this single-center study. GRST was defined as high-intensity statin (HIS) therapy for patients ≤75 years old and moderate-intensity statin (MIS) or HIS therapy for patients75 years. RCR at follow-up was defined as50% decrease in LDL-C with HIS or30% with MIS for statin-naïve patients and as LDL-C70 mg/dL for nonstatin-naïve patients. A total of 2,653 patients were included, with 1,304 (49.2%) discharged with GRST. There was a significant increase in the number of patients discharged with GRST over time from 44.2% in 2010 to 63.0% in 2016 (p0.001). Conversely, RCR at follow-up was present in 1,120 patients (42.2%) overall and remained stable over time. Risk factors of RCR at follow-up were female gender (odds ratio [OR]: 1.38; 95% confidence interval [CI] 1.13 to 1.70), previous myocardial infarction (OR: 1.37; 95% CI 1.12 to 1.64), smoking (OR: 1.30; 95% CI 1.01 to 1.67), higher LDL-C level at baseline (OR: 1.22; 95% CI 1.18 to 1.25). The presence of RCR was associated with an increased adjusted risk of death within 1 year of the second LDL-C measurement (adjHR: 2.78; 95% CI 1.15 to 6.67). In conclusion, although the rate of GRST at discharge has improved significantly over time in patients who underwent elective PCI, the prevalence of RCR at follow-up has not changed appreciably suggesting that further implementation of guidelines as well as novel or more intensive pharmacotherapy may be warranted.
- Published
- 2018
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