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Your search keyword '"Metcalf-Pate, Kelly A."' showing total 5 results
Start Over Author "Metcalf-Pate, Kelly A." Journal the american journal of pathology
5 results on '"Metcalf-Pate, Kelly A."'

1. Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters

Author

Betenbaugh, Michael J., Carlson, Bess, Castell, Natalie, Castillo, Jennie Ruelas, Flavahan, Kelly, Hutchinson, Eric K., Littlefield, Kirsten, Looney, Monika M., Lowman, Maggie, Majewski, Natalia, Maxwell, Amanda, Mota, Filipa, Mueller, Alice L., Ordonez, Alvaro A., Pieterse, Lisa, Quijada, Darla, Ruiz-Bedoya, Camilo A., Stover, Mitchel, Vistein, Rachel, Wood, Melissa, Mulka, Kathleen R., Beck, Sarah E., Solis, Clarisse V., Johanson, Andrew L., Queen, Suzanne E., McCarron, Megan E., Richardson, Morgan R., Zhou, Ruifeng, Marinho, Paula, Jedlicka, Anne, Guerrero-Martin, Selena, Shirk, Erin N., Braxton, Alicia M., Brockhurst, Jacqueline, Creisher, Patrick S., Dhakal, Santosh, Brayton, Cory F., Veenhuis, Rebecca T., Metcalf Pate, Kelly A., Karakousis, Petros C., Zahnow, Cynthia A., Klein, Sabra L., Jain, Sanjay K., Tarwater, Patrick M., Pekosz, Andrew S., Villano, Jason S., and Mankowski, Joseph L.

Published
2022
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2. Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters

Author

Mulka, Kathleen R., primary, Beck, Sarah E., additional, Solis, Clarisse V., additional, Johanson, Andrew L., additional, Queen, Suzanne E., additional, McCarron, Megan E., additional, Richardson, Morgan R., additional, Zhou, Ruifeng, additional, Marinho, Paula, additional, Jedlicka, Anne, additional, Guerrero-Martin, Selena, additional, Shirk, Erin N., additional, Braxton, Alicia M., additional, Brockhurst, Jacqueline, additional, Creisher, Patrick S., additional, Dhakal, Santosh, additional, Brayton, Cory F., additional, Veenhuis, Rebecca T., additional, Metcalf Pate, Kelly A., additional, Karakousis, Petros C., additional, Zahnow, Cynthia A., additional, Klein, Sabra L., additional, Jain, Sanjay K., additional, Tarwater, Patrick M., additional, Pekosz, Andrew S., additional, Villano, Jason S., additional, Mankowski, Joseph L., additional, Betenbaugh, Michael J., additional, Carlson, Bess, additional, Castell, Natalie, additional, Castillo, Jennie Ruelas, additional, Flavahan, Kelly, additional, Hutchinson, Eric K., additional, Littlefield, Kirsten, additional, Looney, Monika M., additional, Lowman, Maggie, additional, Majewski, Natalia, additional, Maxwell, Amanda, additional, Mota, Filipa, additional, Mueller, Alice L., additional, Ordonez, Alvaro A., additional, Pieterse, Lisa, additional, Quijada, Darla, additional, Ruiz-Bedoya, Camilo A., additional, Stover, Mitchel, additional, Vistein, Rachel, additional, and Wood, Melissa, additional

Published
2022
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3. Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus–Infected Macaques Receiving Antiretroviral Therapy

Author

Mangus, Lisa M., primary, Beck, Sarah E., additional, Queen, Suzanne E., additional, Brill, Samuel A., additional, Shirk, Erin N., additional, Metcalf Pate, Kelly A., additional, Muth, Dillon C., additional, Adams, Robert J., additional, Gama, Lucio, additional, Clements, Janice E., additional, and Mankowski, Joseph L., additional

Published
2018
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5. Loss of Corneal Sensory Nerve Fibers in SIV-Infected Macaques An Alternate Approach to Investigate HIV-Induced PNS Damage

Author

Dorsey, Jamie L., Mangus, Lisa M., Oakley, Jonathan D., Beck, Sarah E., Kelly, Kathleen M., Queen, Suzanne E., Metcalf Pate, Kelly A., Adams, Robert J., Marfurt, Carl F., and Mankowski, Joseph L.

Subjects
Short Communication, Simian Acquired Immunodeficiency Syndrome, Peripheral Nervous System Diseases, HIV Infections, eye diseases, Cornea, Nerve Fibers, Glial Fibrillary Acidic Protein, HIV-1, Animals, Simian Immunodeficiency Virus, sense organs, Epidermis, Macaca nemestrina
Abstract

Peripheral neuropathy is the most frequent neurological complication of HIV infection, affecting more than one-third of infected patients, including patients treated with antiretroviral therapy. Although emerging noninvasive techniques for corneal nerve assessments are increasingly being used to diagnose and monitor peripheral neuropathies, corneal nerve alterations have not been characterized in HIV. Here, to determine whether SIV infection leads to corneal nerve fiber loss, we immunostained corneas for the nerve fiber marker βIII tubulin. We developed and applied both manual and automated methods to measure nerves in the corneal subbasal plexus. These counting methods independently indicated significantly lower subbasal corneal nerve fiber density among SIV-infected animals that rapidly progressed to AIDS compared with slow progressors. Concomitant with decreased corneal nerve fiber density, rapid progressors had increased levels of SIV RNA and CD68-positive macrophages and expression of glial fibrillary acidic protein by glial satellite cells in the trigeminal ganglia, the location of the neuronal cell bodies of corneal sensory nerve fibers. In addition, corneal nerve fiber density was directly correlated with epidermal nerve fiber length. These findings indicate that corneal nerve assessment has great potential to diagnose and monitor HIV-induced peripheral neuropathy and to set the stage for introducing noninvasive techniques to measure corneal nerve fiber density in HIV clinical settings.

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