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In undertaking the following animal experiments on the nature of the expulsive action of the gall bladder, we had particularly in mind the investigation of the modus operandi of magnesium sulphate when applied to the papilla of Vater as suggested by Meltzer.Laparotomy and duodenotomy was performed on several dogs anesthetized with chloretone. Observation of the gall bladder immediately after laparotomy showed a distended bladder in all except one animal. The flaccid bladder was seen in a fasting dog.A solution of methylene blue was injected into the gall bladder to differentiate its content from the bile flowing from the liver. The duodenal mucosa in the region of and including the papilla of Vater was irrigated with magnesium sulphate solution; although an increased flow of bile was observed, no expulsion of the gall bladder content was noted. This observation was carried on for several hours in a series of eight dogs. The gall bladder retained its bile independent of whether the dog was in the fasting o...

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