1. Combined ultrasound and serologic screening for hepatic alveolar echinococcosis in central China
- Author
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Yunhai Wang, Philip S. Craig, Patrick Giraudoux, Gitte Bartholomot, Calum N. L. Macpherson, Da Zhong Shi, S Harraga, Guy Barnish, Dominique A. Vuitton, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, SERF Unit, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Xinjiang Medical University, Chinese Government, Biomedical Sciences Research Institute, University of Salford, Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement ( LCE ), and Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC )
- Subjects
Male ,Pathology ,MESH : Aged ,MESH: Echinococcus ,Serology ,0302 clinical medicine ,MESH : Child ,Seroepidemiologic Studies ,MESH: Child ,Surveys and Questionnaires ,MESH : Seroepidemiologic Studies ,MESH : Echinococcus ,MESH : Female ,MESH: Animals ,Child ,Ultrasonography ,MESH: Aged ,0303 health sciences ,MESH: Middle Aged ,biology ,Ultrasound ,MESH: Echinococcosis, Hepatic ,MESH : Questionnaires ,MESH: Enzyme-Linked Immunosorbent Assay ,MESH : Adult ,Middle Aged ,MESH : Enzyme-Linked Immunosorbent Assay ,Echinococcosis ,MESH: China ,3. Good health ,Infectious Diseases ,Female ,medicine.symptom ,Adult ,[ SDV.MP.PAR ] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,China ,Echinococcosis, Hepatic ,medicine.medical_specialty ,Adolescent ,MESH : Male ,030231 tropical medicine ,Antibodies, Helminth ,Helminthiasis ,Enzyme-Linked Immunosorbent Assay ,Echinococcus multilocularis ,Malignancy ,Lesion ,03 medical and health sciences ,MESH: Antibodies, Helminth ,MESH : Adolescent ,Virology ,medicine ,MESH : China ,Animals ,Humans ,MESH : Middle Aged ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,MESH : Antibodies, Helminth ,Aged ,MESH: Adolescent ,MESH: Humans ,MESH: Seroepidemiologic Studies ,030306 microbiology ,business.industry ,MESH: Questionnaires ,MESH : Humans ,MESH: Adult ,biology.organism_classification ,medicine.disease ,MESH: Male ,Echinococcus ,Parasitology ,MESH : Animals ,MESH : Echinococcosis, Hepatic ,business ,MESH: Female - Abstract
International audience; Alveolar echinococcosis (AE), caused by Echinococcus multilocularis, is a zoonotic helminthic disease that can mimic malignancy. In the 1970s, foci of the disease were found in central China. The aim of the present study was to estimate the prevalence of AE in humans in 2 districts of south Gansu Province, China, by use of ultrasound and Echinococcus serology. After answering an epidemiological questionnaire, 2,482 volunteers from 28 villages underwent ultrasound. Serology via enzyme-linked immunosorbent assay for antibody activity was performed on whole blood collected on filter paper in all subjects; on serum from subjects with an abnormal ultrasound image; and on randomly chosen subjects that either had no lesions or had atypical lesions. At least one (25.3%) abnormal ultrasound image was observed in 630 of the subjects screened. A typical lesion of progressive AE was found in 84 subjects (3.4%). Serologies were positive in 77 (96%) of 80 of patients who had lesions typical of progressive AE. Ultrasound is useful for screening for AE in endemic regions.
- Published
- 2002
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