1. Airway Obstruction and Bronchodilator Responsiveness in Adults With Acute Cough
- Author
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Maciek Godycki-Cwirko, Helena Hupkova, Jordi Almirall, Michael Moore, Sławomir Chlabicz, Antoni Torres, An De Sutter, Francesco Blasi, Herman Goossens, Mel Davies, Christopher C Butler, Theo J M Verheij, Tom Schaberg, Paul Little, Saskia van Vugt, Lidewij Broekhuizen, Janko Kersnik, Samuel Coenen, Kerenza Hood, Nicolaas P.A. Zuithoff, and GRACE Project Group
- Subjects
Adult ,Spirometry ,medicine.medical_specialty ,Vital capacity ,medicine.drug_class ,spirometry ,acute cough ,PERSISTENT COUGH ,chronic obstructive pulmonary disease ,Pulmonary Disease, Chronic Obstructive ,FEV1/FVC ratio ,Internal medicine ,Bronchodilator ,GENERAL-PRACTICE ,Prevalence ,Medicine and Health Sciences ,PULMONARY-DISEASE ,medicine ,Humans ,COPD ,Intensive care medicine ,POPULATION ,Original Research ,Asthma ,Primary Health Care ,medicine.diagnostic_test ,business.industry ,Middle Aged ,asthma ,Airway obstruction ,medicine.disease ,Bronchodilator Agents ,PREVALENCE ,respiratory tract diseases ,Airway Obstruction ,Europe ,primary health care ,Cross-Sectional Studies ,Treatment Outcome ,Cough ,Acute Disease ,Human medicine ,SMOKING ,Family Practice ,business - Abstract
PURPOSE: We sought to determine the prevalence of airway obstruction and bronchodilator responsiveness in adults consulting for acute cough in primary care. METHODS: Family physicians recruited 3,105 adult patients with acute cough (28 days or shorter) attending primary care practices in 12 European countries. After exclusion of patients with preexisting physician-diagnosed asthma or chronic obstructive pulmonary disease (COPD), we undertook complete case analysis of spirometry results (n = 1,947) 28 to 35 days after inclusion. Bronchodilator responsiveness was diagnosed if there were recurrent complaints of wheezing, cough, or dyspnea and an increase of the forced expiratory volume in 1 second (FEV(1)) of 12% or more after bronchodilation. Airway obstruction was diagnosed according to 2 thresholds for the (postbronchodilator) ratio of FEV(1) to forced vital capacity (FEV(1):FVC): less than 0.7 and less than the lower limit of normal. RESULTS: There were 240 participants who showed bronchodilator responsiveness (12%), 193 (10%) had a FEV(1)/FVC ratio of less than 0.7, and 126 (6%) had a ratio of less than the lower limit of normal. Spearman's correlation between the 2 definitions of obstruction was 0.71 (P
- Published
- 2012
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