1. The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss
- Author
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Punita Christopher, Fred K. Chen, Mark S. Humayun, Lyndon da Cruz, José Sahel, Jessy D. Dorn, Eugene Filley, Paulo E. Stanga, Varalakshmi Wuyyuru, Francesco Merlini, Robert J. Greenberg, Brian Coley, and Gislin Dagnelie
- Subjects
Adult ,Male ,medicine.medical_specialty ,Visual perception ,Visual acuity ,genetic structures ,medicine.medical_treatment ,Retinal implant ,Visual Acuity ,Vision, Low ,Audiology ,Prosthesis ,Choroideremia ,Prosthesis Implantation ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Ophthalmology ,Retinitis pigmentosa ,medicine ,Humans ,Prospective Studies ,Aged ,business.industry ,Clinical Science ,Middle Aged ,medicine.disease ,Sensory Systems ,Electrodes, Implanted ,Visual Prosthesis ,Reading ,Visual prosthesis ,030221 ophthalmology & optometry ,Visual Perception ,Female ,Implant ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Retinitis Pigmentosa - Abstract
Background Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. Methods We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out. Results The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p
- Published
- 2013