1. A prospective randomized trial of vagotomy in chronic duodenal ulceration
- Author
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Elder Jb, D. R. Shreeve, Cowley Dj, Gillespie Ie, D. G. Ostick, C. D. R. Pengelly, M. Shafiq, I. W. Dymock, P. F. Schofield, Ganguli Pc, D. E. F. Tweedle, M. Palmer, and C. G. Koffman
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Vagotomy ,Pyloroplasty ,law.invention ,Random Allocation ,Duodenal ulceration ,Randomized controlled trial ,law ,Recurrence ,medicine ,Humans ,Pylorus ,Clinical Trials as Topic ,business.industry ,Incidence (epidemiology) ,Significant difference ,Operative mortality ,Surgery ,Clinical trial ,Duodenal Ulcer ,Chronic Disease ,Female ,business - Abstract
Summary In a prospective, randomized trial, 76 patients with duodenal ulceration treated by truncal vagotomy and pyloroplasty were compared with 77 patients who underwent highly selective vagotomy. A total of 149 patients was followed up for from 1 to 4 years, the average follow-up period being 2.6 years. There was no operative mortality and no significant difference in postoperative morbidity between the two groups. The incidence of recurrent ulceration was greater after highly selective vagotomy, but this difference was not statistically significant. The clinical results were comparable in each group, and although the incidence of diarrhoea and dumping was greater after vagotomy and pyloroplasty, this difference was not statistically significant.
- Published
- 1979