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Diabetic cardiomyopathy is defined as left ventricular dysfunction that occurs independently of coronary artery disease, and hypertension. The aim of this study is to investigate early alterations in left ventricular systolic and diastolic functions in patients with type 2 diabetes mellitus using strain and strain rate Echo compared with normal subjects. Patients and methods: he present study enrolled forty subjects. They were divided into two groups: Group (1): Patients with only type 2 diabetes mellitus (20 Patients).Group (2) Normal Subjects as controls (20 Patients).All patients of type 2 diabetes mellitus according to the WHO criteria treated with oral hypo glycemic drugs. Mean age of diabetic group is (53.05 ± 7.02). All the studied groups were subjected to: full history taking and clinical examination, resting 12 leads surface electro-cardiogram, laboratory assessment of Glycosylated Hb, standard trans-thoracic echocardiography, tissue Doppler imaging, strain and strain rate imaging. Results: All of the groups investigated did not differ in EF%, FS, decleration time, isovolumetric relaxation time, E/A ratio. Deterioration of left ventricular systolic and diastolic functions was evident in diabetic group, which was indicated by TDI parameters (significantly lower values of Sm, Em and Em-to-Am ratio). Systolic strain, peak systolic strain rate early and late diastolic strain were significantly lower in patients with type 2 diabetes than in controls. Conclusion: Type 2 diabetes mellitus deteriorate both LV systolic and diastolic performance. Strain and strain rate by tissue Doppler Imaging is superior to conventional Doppler in early detection and evaluation of systolic and diastolic dysfunction in type 2 diabetic patients.