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16 results on '"Eric M. George"'

7. A Novel Anti‐Inflammatory Agent for the Management of Preeclampsia

Author

Heather Chapman, Fakhri Mahdi, Gene L. Bidwell, Eric M. George, and Adrian C Eddy

Subjects
medicine.drug_class, business.industry, Immunology, Genetics, medicine, business, medicine.disease, Molecular Biology, Biochemistry, Anti-inflammatory, Biotechnology, Preeclampsia
Published
2018

9. Daily Inhaled Low‐Dose Carbon Monoxide Does Not Improve Hypertension Associated with Placental Ischemia

Author

Eric M. George and Joey P. Granger

Subjects
Pregnancy, medicine.medical_specialty, Proteinuria, business.industry, Low dose, Ischemia, Hypertensive disorder, medicine.disease, Biochemistry, female genital diseases and pregnancy complications, Preeclampsia, Internal medicine, Genetics, medicine, Cardiology, Endothelial dysfunction, medicine.symptom, business, Molecular Biology, reproductive and urinary physiology, Biotechnology
Abstract

Preeclampsia is a hypertensive disorder of pregnancy characterized by hypertension, proteinuria, and maternal endothelial dysfunction. While the underlying cause is still an active area of investig...

Published
2015

10. A corneal penetrating drug delivery system based on elastin‐like polypeptide (1053.4)

Author

Mary Marquart, Huiling Liu, Eric M. George, Grant Robinson, and Gene L. Bidwell

Subjects
Tight junction, biology, Chemistry, Penetration (firestop), Biochemistry, eye diseases, medicine.anatomical_structure, Cornea, Drug delivery, Genetics, medicine, Biophysics, biology.protein, sense organs, Molecular Biology, Layer (electronics), Elastin, Biotechnology, Corneal epithelium
Abstract

The corneal epithelium is connected by tight junctions and serves as a protective layer, but its resistance to penetration also presents a challenge to drug delivery. Upon injury, the cornea is sus...

Published
2014

11. Co‐releasing molecules attenuate placental ischemia‐induced hypertension in pregnant rats (1084.4)

Author

David E. Stec, Eric M. George, and Joey P. Granger

Subjects
medicine.medical_specialty, Pregnancy, Bilirubin, business.industry, Ischemia, medicine.disease, Biochemistry, Preeclampsia, chemistry.chemical_compound, Blood pressure, Endocrinology, chemistry, Internal medicine, Decreased blood pressure, Genetics, medicine, Endothelial dysfunction, business, Molecular Biology, Ex vivo, Biotechnology
Abstract

Preeclampsia is a serious complication of pregnancy marked by hypertension and maternal endothelial dysfunction. Recently we have published a series of studies demonstrating that induction of heme oxygenase-1 (HO-1) could attenuate many of the maternal symptoms of preeclampsia in a rodent model of placental ischemia induced by Reductions on Uterine Perfusion Pressure (RUPP). We have further shown that the individual metabolites of HO-1, namely CO and bilirubin, both downregulate hypoxia-induced production of known placental derived pathogenic factors ex vivo. Here, we tested whether , administration of the CO-releasing molecule CORM-3 could attenuate the maternal symptoms of placental ischemia. In response to placental ischemia, rats exhibited marked increases in blood pressure compared to control animals (107 ± 1 vs 136 ± 2mmHg, p

Published
2014

14. Hyperinsulinemia increases blood pressure and pup weight in pregnant rats

Author

Kathy Cockrell, Eric M. George, Marietta Arany, Ana Taveiros Palei, and Joey P. Granger

Subjects
medicine.medical_specialty, Endocrinology, Blood pressure, business.industry, Internal medicine, Genetics, medicine, Hyperinsulinemia, medicine.disease, business, Molecular Biology, Biochemistry, Biotechnology
Published
2012

15. Sildenafil Administration Attenuates Placental Ischemia and sFlt‐1 Induced Hypertension in Pregnant Rats

Author

Eric M. George, Marietta Arany, Joey P. Granger, and Kathy Cockrell

Subjects
medicine.medical_specialty, Sildenafil, Ischemia, urologic and male genital diseases, Biochemistry, Gastroenterology, Preeclampsia, chemistry.chemical_compound, Internal medicine, Genetics, Medicine, Endothelial dysfunction, Molecular Biology, reproductive and urinary physiology, Pregnancy, Proteinuria, business.industry, medicine.disease, female genital diseases and pregnancy complications, chemistry, embryonic structures, Etiology, medicine.symptom, business, Complication, Biotechnology
Abstract

Preeclampsia is a complication of pregnancy which is marked by hypertension, proteinuria, and maternal endothelial dysfunction. A central factor in the etiology of the disease is the development of...

Published
2012

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