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1. Study the Effects of Capsaicin on Triple Negative Breast Cancer Cells

Author

Timothy J. Maher, Rawabi A. Alashari, Moudi M. Alasmari, Mark Böhlke, Heba K. Alshaeri, and Alejandro Pino-Figueroa

Subjects
0301 basic medicine, business.industry, Estrogen receptor, Cancer, medicine.disease, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Breast cancer, chemistry, Capsaicin, Genetics, Cancer research, medicine, skin and connective tissue diseases, business, Molecular Biology, 030217 neurology & neurosurgery, Triple-negative breast cancer, Biotechnology
Abstract

Triple negative breast cancer (TNBC) is one of the most aggressive types of breast cancer accounting for 12% of breast cancer cases. It is characterized by the lack of the estrogen receptor (ER), p...

Published
2019
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2. Inhibitory effect of macamides: N ‐benzylpalmitamide and N ‐(3‐methoxybenzyl)palmitamide on fatty acid amide hydrolase (FAAH)

Author

Timothy J. Maher, Mariam Alamoudi, Alejandro Pino-Figueroa, and Mark Böhlke

Subjects
Folk medicine, Lepidium meyenii, Traditional medicine, Fatty acid amide hydrolase, Chemistry, Genetics, Palmitamide, Molecular Biology, Biochemistry, Inhibitory effect, Biotechnology
Abstract

Lepidium meyenii (Maca), a Peruvian plant, has been used as a folk medicine for centuries. Recent studies have indicated that Maca extracts and their active constituents, macamides, act as inhibito...

Published
2015
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3. Endothelial Nitric Oxide Synthase (eNOS) Blockade Within the Ventrolateral Medulla Differentially Modulates the Exercise Pressor Reflex in Stroked‐Rats

Author

Pasarapa Towiwat, Siripan Phattanarudee, Ahmmed Ally, and Timothy J. Maher

Subjects
medicine.medical_specialty, Endothelial nitric oxide synthase, biology, Chemistry, Rostral ventrolateral medulla, biology.organism_classification, Biochemistry, Blockade, Endocrinology, Enos, Internal medicine, Genetics, medicine, Reflex, Molecular Biology, Medulla, Biotechnology
Abstract

We have previously shown that blockade of endothelial nitric oxide synthase (eNOS) within the rostral (RVLM) and caudal ventrolateral medulla (CVLM) differentially modulates cardiovascular response...

Published
2015
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5. Inducible nitric oxide synthase blockade within the ventrolateral medulla differentially modulates the exercise pressor reflex in stroke rats (681.5)

Author

Michael Phillips, Timothy J. Maher, Andrew Hoppenrath, and Ahmmed Ally

Subjects
medicine.medical_specialty, biology, business.industry, Rostral ventrolateral medulla, medicine.disease, Biochemistry, Blockade, Nitric oxide synthase, Endocrinology, Anesthesia, Internal medicine, Genetics, medicine, biology.protein, Reflex, business, Molecular Biology, Stroke, Medulla, Biotechnology
Published
2014
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6. Neuroprotective effects of Lepidium meyenii (Maca) and macamides against amyloid‐beta (25‐35) induced toxicity in B‐35 neuroblastoma cells (657.13)

Author

Alejandro Pino-Figueroa, Timothy J. Maher, Mark Bӧhlke, Dania Waggas, and Ali Alquraini

Subjects
chemistry.chemical_classification, Lepidium meyenii, biology, Chemistry, Amyloid beta, Peptide, Pharmacology, Biochemistry, Neuroprotection, Maca plant, Neuroblastoma cell, Toxicity, Genetics, biology.protein, Molecular Biology, Biotechnology
Abstract

Production and deposition of Amyloid-beta (Aβ) peptide is a hallmark of Alzheimer’s disease. The Maca plant (Lepidium meyenii) has been used as a traditional medicine to treat several diseases. It ...

Published
2014
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9. In vitro neuroprotective activity of phenibut

Author

Timothy J. Maher, Daisy Huynh, Chong Shun Wai, Anna Liang, and Alejandro Pino-Figueroa

Subjects
chemistry.chemical_compound, Chemistry, Phenibut, Genetics, medicine, Pharmacology, Molecular Biology, Biochemistry, Neuroprotection, In vitro, Derivative (chemistry), Biotechnology, medicine.drug
Abstract

Phenibut, a derivative of gamma-aminobutyric acid (GABA) is said to exhibit neurological properties. Pharmacological studies are necessary to understand its full potential as a therapeutic agent an...

Published
2012
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10. Effects of medullary administration of nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise in stroke rats

Author

Siripan Phattanarudee, Ehtesham Shafique, Timothy J. Maher, and Ahmmed Ally

Subjects
medicine.medical_specialty, Medullary cavity, business.industry, Neurotransmission, medicine.disease, Biochemistry, Nitric oxide, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Genetics, Medicine, business, Static Exercise, Molecular Biology, Stroke, Biotechnology
Published
2012
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11. A possible cannabinergic neuroprotective mechanism of action of Lepidium meyenii (Maca)

Author

Timothy J. Maher and Alejandro Pino-Figueroa

Subjects
Cannabinoid receptor, Lepidium meyenii, Chemistry, medicine.medical_treatment, food and beverages, Pharmacology, Biochemistry, Neuroprotection, Mechanism of action, Genetics, medicine, lipids (amino acids, peptides, and proteins), Cannabinoid, medicine.symptom, Receptor, Molecular Biology, Biotechnology
Abstract

The pentane extract of the plant Lepidium meyenii (Maca), has been shown to possess neuroprotective activity. This study was designed to examine the involvement of cannabinoid CB1 receptors in the ...

Published
2010
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12. Effect of Acetyl‐L‐Carnitine (ALCAR) on the Striatal Outflow of Various Neurotransmitters Using Microdialysis and the Role of the GLT‐1/EAA‐2 Glutamate Transporter During Middle Cerebral Artery Occlusion (MCAO) in Rats

Author

Timothy J. Maher, Mark Böhlke, and Fakhreya Yousuf Jalal

Subjects
Microdialysis, biology, Chemistry, Excitatory amino-acid transporter, Anesthesia, Genetics, Acetyl-L-carnitine, biology.protein, Middle cerebral artery occlusion, Pharmacology, Molecular Biology, Biochemistry, Biotechnology
Published
2009
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19. ENDOTHELIAL NITRIC OXIDE SYNTHASE (eNOS) WITHIN THE PERIAQUEDUCTAL GRAY MATTER DIFFERENTIALLY MODULATES NEUROTRANSMISSION AND CARDIOVASCULAR RESPONSES DURING MECHANICAL, HEAT, AND COLD NOCICEPTION

Author

Ahmmed Ally, Mark Böhlke, Timothy J. Maher, Kevin A. Chaitoff, Allisa Nolan, and Dipan Patel

Subjects
medicine.medical_specialty, Endothelial nitric oxide synthase, biology, Chemistry, Neurotransmission, biology.organism_classification, Biochemistry, Nociception, Endocrinology, Periaqueductal gray matter, Enos, Internal medicine, Genetics, medicine, Molecular Biology, Biotechnology
Published
2008
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21. Blockade of neuronal nitric oxide synthase (nNOS) within the periaqueductal gray (PAG) differentially modulates neurotransmission and cardiovascular responses during mechanical and thermal nociception

Author

Timothy J. Maher, Ahmmed Ally, Mark Böhlke, Kevin A. Chaitoff, Gudbjorn A. Karlsson, and Shamma Hossain

Subjects
Chemistry, Thermal nociception, Genetics, Neurotransmission, Molecular Biology, Biochemistry, Periaqueductal gray, Neuronal Nitric Oxide Synthase, Neuroscience, Biotechnology, Blockade
Published
2007
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22. EFFECTS OF ENDOTHELIAL NOS ANTAGONISM ON ENDOTHELIAL NOS EXPRESSION WITHIN THE VENTROLATERAL MEDULLA AND CARDIOVASCULAR RESPONSES DURING STATIC SKELETAL MUSCLE CONTRACTION

Author

Shruti V. Kabadi, Siripan Phattanarudee, Timothy J. Maher, Maitreyee Patel, and Ahmmed Ally

Subjects
medicine.medical_specialty, Endocrinology, Chemistry, Skeletal muscle contraction, Internal medicine, Genetics, medicine, Antagonism, Endothelial NOS, Molecular Biology, Biochemistry, Medulla, Biotechnology
Published
2007
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