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31 results on '"Jianhua, Li"'

2. IL‐1β‐Induced Thermoregulation and Vagus Nerve Activity is Mediated by Transient Receptor Potential Ankyrin 1

Author

Eric H. Chang, Jianhua Li, Sangeeta S. Chavan, Qiong Zeng, Tea Tsaava, Manojkumar Gunasekaran, Kevin J. Tracey, Valentin A. Pavlov, Harold A. Silverman, Dane Thompson, Meghan E. Addorisio, and Qing Chang

Subjects
chemistry.chemical_classification, Transient receptor potential channel, chemistry, Genetics, Ankyrin, Thermoregulation, Molecular Biology, Biochemistry, Biotechnology, Vagus nerve, Cell biology
Published
2021

3. Induction of Pro‐Inflammatory Cytokines TNF, IL‐6, and HMGB1 by SARS‐CoV‐2 Spike Proteins in Mice and in Murine Macrophage Cultures

Author

Kevin J. Tracey, Jianhua Li, Ulf Andersson, Eric H. Chang, Sam George, Huan Yang, Sangeeta S. Chavan, and Aisling Tynan

Subjects
2019-20 coronavirus outbreak, biology, Physiology, Inflammation, Immune system and Autonomic Regulation, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), HMGB1, Biochemistry, Proinflammatory cytokine, Immunology, Genetics, biology.protein, Macrophage, Tumor necrosis factor alpha, Spike (database), Interleukin 6, Molecular Biology, Biotechnology
Abstract

The pandemic COVID‐19 disease with severe acute respiratory syndrome (SARS) is mediated by the coronavirus SARS‐CoV‐2. The highly conserved surface spike glycoprotein of the SARS‐coronavirus is critical for viral entry into cells, a central step in pathogenesis. To further understand and characterize viral spike proteins in host cell immune responses, we generated two species of spike proteins: a recombinant receptor binding domain (RBD) and a truncated part of RBD, the receptor binding motif (RBM). In cell cultures with murine macrophage‐like RAW 264.7 cells or with thioglycollate‐elicited peritoneal primary mouse macrophages, recombinant RBD and RBM dose‐dependently induced the release of TNF and HMGB1, pro‐inflammatory molecules observed in increased systemic levels in COVID‐19 patients (Chen R et al, Heliyon 6, 2020, e05672). Intratracheal administration of RBD (100 µg/mouse) or RBM (100 µg/mouse) also induced HMGB1 release in bronchoalveolar lung (BAL) fluid at 24 hours post‐instillation (HMGB1 levels = 71 ± 30 ng/mL in PBS group vs. 253 ± 19* ng/mL in RBD group and 284 ± 42* ng/mL in RBM group; n=3‐4 mice/group; *: p

Published
2021

5. Anti‐Inflammatory Effects of Famotidine

Author

Huan Yang, Sangeeta S. Chavan, Harold A. Silverman, Sam George, Ulf Andersson, Jianhua Li, Dane Thompson, Kevin J. Tracey, Eric H. Chang, and Aisling Tynan

Subjects
Famotidine, business.industry, medicine.drug_class, Genetics, medicine, Pharmacology, business, Molecular Biology, Biochemistry, Anti-inflammatory, Biotechnology, medicine.drug
Published
2021

17. Cyclooxygenase‐2 (COX‐2) Pathway Expression within Skeletal Muscle in Relation to Exaggerated Exercise Pressor Reflex in Congestive Heart Failure

Author

Wei Gao, Ariel Morales, and Jianhua Li

Subjects
medicine.medical_specialty, biology, business.industry, Skeletal muscle, medicine.disease, Biochemistry, medicine.anatomical_structure, Endocrinology, Expression (architecture), Heart failure, Internal medicine, Genetics, Reflex, biology.protein, medicine, Cyclooxygenase, business, Molecular Biology, Biotechnology
Published
2011

23. Cyclooxygenase products contribute to enhanced muscle reflex in heart failure

Author

Jianhua Li, Jihong Xing, Satoshi Koba, and Lawrence I. Sinoway

Subjects
medicine.medical_specialty, biology, business.industry, medicine.disease, Biochemistry, Heart failure, Internal medicine, Genetics, biology.protein, Reflex, Cardiology, medicine, Cyclooxygenase, business, Molecular Biology, Biotechnology
Published
2008

24. TRPV1‐mediated sympathetic responsiveness in hindlimb muscle ischemia

Author

Jihong Xing, Lawrence I. Sinoway, Zhaohui Gao, Jianhua Li, and Jian Lu

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Genetics, medicine, TRPV1, Hindlimb, business, Molecular Biology, Biochemistry, Muscle ischemia, Biotechnology
Published
2008

27. Temperature response in contracting skeletal muscle after myocardial infraction

Author

Jihong Xing, Lawrence I. Sinoway, Zhaohui Gao, and Jianhua Li

Subjects
medicine.medical_specialty, medicine.anatomical_structure, business.industry, Internal medicine, Genetics, medicine, Cardiology, Skeletal muscle, business, Molecular Biology, Biochemistry, Temperature response, Biotechnology
Published
2007

28. Enhanced norepinephrine concentrations in interstitium of skeletal muscle after myocardial infarction

Author

Valerie Kehoe, Jianhua Li, Jihong Xing, Lawrence I. Sinoway, N. King, and Satoshi Koba

Subjects
medicine.medical_specialty, business.industry, Skeletal muscle, medicine.disease, Biochemistry, Norepinephrine (medication), medicine.anatomical_structure, Internal medicine, Genetics, medicine, Cardiology, Myocardial infarction, business, Molecular Biology, Biotechnology, medicine.drug
Published
2007

29. P2X receptor‐mediated muscle pressor reflex in myocardial infarction (MI)

Author

Lawrence I. Sinoway, Zhaohui Gao, and Jianhua Li

Subjects
medicine.medical_specialty, business.industry, Receptor-mediated endocytosis, medicine.disease, Biochemistry, Internal medicine, Genetics, medicine, Cardiology, Reflex, Myocardial infarction, business, Molecular Biology, Biotechnology
Published
2006

30. Norepinephrine (NE) concentrations in exercising muscle with myocardial infarction: Implications for cardiovascular regulation in heart failure (HF)

Author

Valerie Kehoe, Lawrence I. Sinoway, Kristen Rice, Zhaohui Gao, Jianhua Li, and N. King

Subjects
medicine.medical_specialty, business.industry, medicine.disease, Biochemistry, Norepinephrine (medication), Heart failure, Internal medicine, Genetics, Cardiology, Medicine, Myocardial infarction, business, Molecular Biology, Biotechnology, medicine.drug
Published
2006

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