The diabetic foot represents one of the major complications of diabetes, posing a tremendous impact on morbidity and mortality. Overall, 1 out of 4 patients with diabetes runs the risk of developing a foot lesion throughout his or her life. Worldwide, the prevalence of the diabetic foot in population-based studies ranges between 1.4% and 5.9%. In Greece, this prevalence has been reported at 4.75%. Diabetic foot ulcers represent the main cause of amputations. Hence, both established and emerging treatment modalities should be diligently applied in an attempt to reduce ulcers and amputations. In Greece, Doupis et al reported that the majority of diabetic foot patients had neuropathic (64.9%) rather than neuroischemic ulcers (35.1%). By contrast, Skoutas et al reported 52.1% frequency of neuroischemic, 17.9% frequency of ischemic, and 30% frequency of neuropathic ulceration. The latter authors have suggested that the frequency of the neuroischemic foot is rising in Greece. Of note, there is some evidence of significantly greater age and longer diabetes duration, male preponderance, as well as increased morbidity among neuroischemic in comparison with neuropathic foot patients and significantly higher frequency of smoking, hypertension, dyslipidemia, retinopathy, nephropathy, and coronary artery disease. Very little is known on the frequency of amputations in Greece. Karagianni reported a prevalence of 12.5/1000 patients in 1999, equivalent to 2.48/10 000 general population, mean 10-year incidence of amputations (1990-1999) was 3.7/1000 patients per year, equivalent to 0.59/10 000 general population per year. It was also reported that amputees suffered a mortality of 56%, which represented a 3-fold increase compared with the general population. Above knee amputations were 18%, below knee 18%, foot 29%, and toe 35%; importantly, 15% of amputations were bilateral. Furthermore, revascularization was only attempted in a minority of those patients, whereas the majority was treated by general surgeons of district hospitals. Repeat amputations are also reported to be more frequent. Papazafiropoulou et al observed that patients with diabetes required a second amputation and a contralateral amputation significantly more frequently than their nondiabetic peers. Skoutas et al found that ipsilateral re-amputation was required in 21.5% of patients during a mean follow-up of 18 months, whereas most re-amputations were performed within the first 6 months of the initial operation, age (hazard ratio 1.06 by increase of 1 year) and heel lesions (hazard ratio 2.69) were significantly associated with ipsilateral re-amputations based on multiple regression analysis of the data. Paradoxically, an initial choice of distal amputation in an attempt to minimize tissue loss increased the risk of ipsilateral re-amputation, especially in older subjects (≥70 years). Revascularization procedures, which may be either bypass surgery or percutaneous transluminal angioplasty, appear not to be used enough, although data are sparse. In 1999, underuse of femorodistal bypass surgery and similar revascularization procedures in Greece was reported. Since then, considerable progress seems to have been made. There are now 14 vascular departments accredited for training and about 200 vascular surgeons in the country. Substantial progress has also been accomplished in interventional radiology facilities, resulting in increased number of angioplasties. However, actual data of this progress are not yet available. Of further significance, revascularization is possible in large cities, but remains little available in small hospitals, leading to substantial geographical variation. Infection of chronic foot ulcers represents a major problem, especially in the presence of ischemia. Methicillin-resistant Stapylococcus aureus (MRSA) is a notorious microorganism, whose prevalence is very high in patients with infected foot ulcers. It is also alarming that MRSA infection or colonization was not associated with known risk factors, reflecting its increased prevalence in the community. When conservative medical measures fail to heal, surgery offering either wound incision and drainage, or amputation should follow. However, there is a lack of unanimity concerning the optimal timing and aggressiveness for such intervention. Against this background, the improvement in the study of the diabetic foot in Greece that has taken place since 2005 is of some reassurance. It was in this, the year of the diabetic foot, that specialists established the Greek Association for the Study of the Diabetic Foot and the Study Group of Neuropathy–Diabetic Foot of the Greek Diabetes Association. Thanks to these societies, more than 10 scientific meetings on the diabetic foot, targeting both local and nationwide