1. Association analysis of serotonin transporter promoter gene polymorphism with ADHD and related symptomatology
- Author
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Lin-Yan Su, Qiao-Rong Su, Yuhu Zhang, Chun-Xiang Huang, Ai-Ling Zhao, Bei-Sha Tang, and Xue-Rong Luo
- Subjects
Male ,medicine.medical_specialty ,Nerve Tissue Proteins ,Bioinformatics ,Polymerase Chain Reaction ,chemistry.chemical_compound ,Polymorphism (computer science) ,mental disorders ,medicine ,Attention deficit hyperactivity disorder ,Humans ,Allele ,Psychiatry ,Neurotransmitter ,Child ,Promoter Regions, Genetic ,Somatoform Disorders ,Serotonin transporter ,Alleles ,Genetic association ,Serotonin Plasma Membrane Transport Proteins ,Membrane Glycoproteins ,Polymorphism, Genetic ,biology ,General Neuroscience ,Membrane Transport Proteins ,Promoter ,General Medicine ,medicine.disease ,chemistry ,Attention Deficit Disorder with Hyperactivity ,Child, Preschool ,biology.protein ,Female ,Serotonin ,Psychology - Abstract
Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop attention deficit hyperactivity disorder. Several investigations have reported associations between ADHD and serotonin transporter promoter polymorphisms, but the results have been inconsistent. The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele.
- Published
- 2005