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Your search keyword '"Howard, Timothy D"' showing total 16 results
Start Over Author "Howard, Timothy D" Journal the journal of allergy and clinical immunology
16 results on '"Howard, Timothy D"'

1. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients

Author

Li, Xingnan, Hawkins, Gregory A., Ampleford, Elizabeth J., Moore, Wendy C., Li, Huashi, Hastie, Annette T., Howard, Timothy D., Boushey, Homer A., Busse, William W., Calhoun, William J., Castro, Mario, Erzurum, Serpil C., Israel, Elliot, Lemanske, Robert F., Jr., Szefler, Stanley J., Wasserman, Stephen I., Wenzel, Sally E., Peters, Stephen P., Meyers, Deborah A., and Bleecker, Eugene R.

Published
2013
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3. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

Author

Torgerson, Dara G., Capurso, Daniel, Ampleford, Elizabeth J., Li, Xingnan, Moore, Wendy C., Gignoux, Christopher R., Hu, Donglei, Eng, Celeste, Mathias, Rasika A., Busse, William W., Castro, Mario, Erzurum, Serpil C., Fitzpatrick, Anne M., Gaston, Benjamin, Israel, Elliot, Jarjour, Nizar N., Teague, W. Gerald, Wenzel, Sally E., Rodríguez-Santana, José R., Rodríguez-Cintrón, William, Avila, Pedro C., Ford, Jean G., Barnes, Kathleen C., Burchard, Esteban G., Howard, Timothy D., Bleecker, Eugene R., Meyers, Deborah A., Cox, Nancy J., Ober, Carole, and Nicolae, Dan L.

Published
2012
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5. Importance of hedgehog interacting protein and other lung function genes in asthma

Author

Li, Xingnan, Howard, Timothy D., Moore, Wendy C., Ampleford, Elizabeth J., Li, Huashi, Busse, William W., Calhoun, William J., Castro, Mario, Chung, Kian Fan, Erzurum, Serpil C., Fitzpatrick, Anne M., Gaston, Benjamin, Israel, Elliot, Jarjour, Nizar N., Teague, W. Gerald, Wenzel, Sally E., Peters, Stephen P., Hawkins, Gregory A., Bleecker, Eugene R., and Meyers, Deborah A.

Published
2011
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15. Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4and CD28

Author

Howard, Timothy D., Postma, Dirkje S., Hawkins, Gregory A., Koppelman, Gerard H., Zheng, Siqun L., Wysong, Alicia K.S., Xu, Jianfeng, Meyers, Deborah A., and Bleecker, Eugene R.

Abstract

Background: Several genomic regions have been identified that might contain genes contributing to the development of asthma and atopy. These include chromosome 2q33, where we have observed evidence for linkage for variation in total serum IgE levels in a Dutch asthma population. Two candidate genes, CTLA4and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region. Objective: We sought to fine-map the chromosome 2q33 region and evaluate CTLA4and CD28as candidate genes for the regulation of total serum IgE levels and related phenotypes. Methods: The coding regions of CTLA4and CD28 were resequenced in 96 individuals; 4 novel SNPs in CTLA4and 10 in CD28were identified. Polymorphisms in both genes were analyzed in 200 asthmatic probands and their spouses (n = 201). Results: Subsequent fine- mapping in this region has resulted in an increased log of the odds (lod) score (1.96 to 3.16) for total serum IgE levels. For CTLA4, the +49 A/G single nucleotide polymorphism (SNP) in exon 1 and the 3′ untranslated region microsatellite were significantly associated with total serum IgE levels (P=.0005 and .006, respectively). For the combined +49 A/G and 3′untranslated region genotypes, individuals homozygous for the risk allele for both polymorphisms (AA and 86/86) had the highest total serum IgE values (87.1 IU/mL), whereas those individuals with the GG and XX/XX genotypes (anything but the 86-bp allele) had the lowest IgE values (29.3 IU/mL). Significant association was also observed for the CTLA4−1147 C/T SNP with bronchial hyperresponsiveness (BHR) and asthma (P= .008 and .012, respectively), but not for allergy-related phenotypes. Promoter luciferase assays examining the −1147 polymorphism suggested that the T allele, which was associated with increased BHR susceptibility, was expressed at half the level of the C allele. Individuals with the risk genotypes for both BHR (−1147 CT or TT) and elevated IgE levels (+49 AA) were 4.5 times more likely to have asthma than individuals with both nonrisk genotypes (P= .0009). No significant associations were observed for SNPs in CD28. Conclusion: These data suggest that the costimulatory pathway, specifically CTLA4, is important in the development of atopy and asthma. (J Allergy Clin Immunol 2002;110:743-51.)

Published
2002
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