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Start Over Descriptor "Griseolic acid" Journal the journal of antibiotics
2 results on '"Griseolic acid"'

1. Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. I. Taxonomy, isolation and characterization

Author

Takao Okazaki, Atsushi Naito, Mitsuo Yamazaki, Fumio Nakagawa, and Yasuteru Iijima

Subjects
Adenosine, Chemical Phenomena, Stereochemistry, Griseolic acid, In Vitro Techniques, chemistry.chemical_compound, Streptomyces griseoaurantiacus, Drug Discovery, Cyclic AMP, medicine, Animals, Moiety, Aorta, Pharmacology, chemistry.chemical_classification, Phosphodiesterase, Phosphate, Streptomyces, Rats, Chemistry, Enzyme, Adenosine 3 5 monophosphate, chemistry, Biochemistry, 3',5'-Cyclic-AMP Phosphodiesterases, medicine.drug
Abstract

Griseolic acid, a potent inhibitor of cyclic adenosine 3',5'-monophosphate (cyclic AMP) phosphodiesterase (EC 3.1.4.17) was isolated from the cultured broth of Streptomyces griseoaurantiacus SANK 63479. Griseolic acid has an adenine moiety and two carboxyl groups and possesses the molecular formula C14H13N5O8. Griseolic acid inhibited cyclic AMP phosphodiesterase competitively with regard to cyclic AMP, the substrate and the resulting Ki value was 0.26 microM. Griseolic acid showed the most potent inhibitory effect on rat aorta cyclic AMP phosphodiesterase among the enzymes of several rat organs tested. The plasma level of cyclic AMP was increased when griseolic acid was subcutaneously injected rats.

Published
1985
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2. Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid

Author

Chihiro Tamura, Shuji Takahashi, Atsushi Naito, Kayoko Kawazoe, Sadao Sato, Yoji Furukawa, and Fumio Nakagawa

Subjects
Adenosine, Magnetic Resonance Spectroscopy, Stereochemistry, Molecular Conformation, Griseolic acid, Streptomyces griseoaurantiacus, Drug Discovery, medicine, Chemical decomposition, Pharmacology, Chromatography, Crystallography, biology, Cyclic nucleotide phosphodiesterase, Chemistry, Hydrolysis, Methanol, Phosphodiesterase, Acetylation, Adenine nucleoside, Biochemistry, Diazomethane, Enzyme inhibitor, 3',5'-Cyclic-AMP Phosphodiesterases, biology.protein, medicine.drug
Abstract

Griseolic acid, a potent inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.

Published
1985

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