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Start Over Descriptor "lavendamycin" Journal the journal of antibiotics
3 results on '"lavendamycin"'

1. Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. II. Physico-chemical properties and structure elucidations

Author

Hideaki Uchida, Masanobu Munekata, Nobuyasu Enoki, Takehiko Nakamura, Yasukazu Nakakita, and Naoki Abe

Subjects
Pharmacology, Antibiotics, Antineoplastic, Magnetic Resonance Spectroscopy, biology, Stereochemistry, Streptomycetaceae, Chromophore, biology.organism_classification, Streptomyces, Mass Spectrometry, chemistry.chemical_compound, chemistry, Spectrophotometry, Drug Discovery, Molecule, Fermentation, Streptonigrin, Actinomycetales, Lavendamycin, Bacteria, Carbolines
Abstract

Novel cytocidal compounds designated oxopropalines A, B, D, E and G were isolated from the fermentation of an actinomycete named Streptomyces sp. G324, a strain that also produced an antitumor antibiotic, lavendamycin. All these compounds possessed a beta-carboline chromophore. The structures of the oxopropalines were elucidated by several NMR spectral analyses and other spectroscopic experiments.

Published
1993
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2. Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. I. Taxonomy of the producing organism, fermentation, isolation and biological activities

Author

Nobuyasu Enoki, Suguru Takeo, Hideaki Uchida, Masanobu Munekata, Takehiko Nakamura, Yasukazu Nakakita, and Naoki Abe

Subjects
Pharmacology, Antibiotics, Antineoplastic, biology, Streptomycetaceae, biology.organism_classification, Streptomyces, In vitro, Microbiology, chemistry.chemical_compound, Mice, chemistry, Drug Discovery, Fermentation, Tumor Cells, Cultured, Animals, Humans, Actinomycetales, Streptonigrin, Lavendamycin, Cytotoxicity, Bacteria, Chromatography, High Pressure Liquid, Carbolines
Abstract

In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp. G324 was found to produce the antitumor antibiotic, lavendamycin, and also, to yield the novel beta-carboline compounds, oxopropalines. We isolated five compounds as oxopropalines A, B, D, E and G. Oxopropalines B, D and G showed cytocidal activities against human or murine tumor cell lines in vitro.

Published
1993

3. Isolation of lavendamycin, a new antibiotic from Streptomyces lavendulae

Author

D. M. Balitz, F. A. O'herron, Bush James A, William T. Bradner, Donald E. Nettleton, and Terrence W. Doyle

Subjects
medicine.drug_class, Antibiotics, Thin layer, Streptomyces, Microbiology, chemistry.chemical_compound, Mice, Drug Discovery, medicine, Animals, Streptonigrin, Lavendamycin, Cells, Cultured, Chromatography, High Pressure Liquid, Pharmacology, Antibiotics, Antineoplastic, biology, Bacteria, Leukemia P388, biology.organism_classification, Isolation (microbiology), Anti-Bacterial Agents, chemistry, Streptomyces lavendulae, Chromatography, Thin Layer
Abstract

The isolation of lavendamycin (1) an antibiotic closely related to streptonigrin (2) is described. Details of the taxonomic description ofS. lavendulae(strain C-22, 030), production of lavendamycin, its isolation and the biological activity are given.

Published
1982

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