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Background: Disc replacement arthroplasty previously has been shown to be an effective alternative to spine fusion for the treatment of single-level lumbar degenerative disc disease. The purpose of the present study was to determine the twenty-four-month results of a clinical trial of the ProDisc-L total disc replacement as compared with spinal fusion for the treatment of degenerative disc disease at two contiguous vertebral levels from L3 to S1. Methods: A total of 237 patients were treated in a randomized controlled trial designed as a non-inferiority study for regulatory application purposes. Blocked randomization was performed with use of a 2:1 ratio of total disc arthroplasty to circumferential arthrodesis. Evaluations, including patient self-assessments, physical and neurological examinations, and radiographic examinations, were performed preoperatively, six weeks postoperatively, and three, six, twelve, eighteen, and twenty-four months postoperatively. Results: At twenty-four months, 58.8% (eighty-seven) of 148 patients in the total disc replacement group were classified as a statistical success, compared with 47.8% (thirty-two) of sixty-seven patients in the arthrodesis group; non-inferiority was demonstrated. The mean Oswestry Disability Index in both groups significantly improved from baseline (p < 0.0001); the mean percentage improvement for the total disc replacement group was significantly better than that for the arthrodesis group (p = 0.0282). An established clinical criterion for success, a ≥15-point improvement in the Oswestry Disability Index from baseline, occurred in 73.2% (109) of 149 patients in the total disc replacement group and 59.7% (thirty-seven) of sixty-two patients in the arthrodesis group. The Short Form-36 physical component scores were significantly better for the total disc replacement group as compared with the arthrodesis group (p = 0.0141 at twenty-four months). Visual analog scale scores for satisfaction significantly favored total disc replacement from three to twenty-four months. At twenty-four months, 78.2% (111) of 142 patients in the total disc replacement group and 62.1% (thirty-six) of fifty-eight patients in the arthrodesis group responded “yes” when asked if they would have the same surgery again. Lumbar spine range of motion on radiographs averaged 7.8° at the superior disc and 6.2° at the inferior disc in patients with total disc replacement. Reduction in narcotics usage significantly favored the total disc replacement group at twenty-four months after surgery (p = 0.0020). Conclusions: Despite the relatively short duration of follow-up and design limitations, the present study suggests that two-level lumbar disc arthroplasty is an alternative to and offers clinical advantages in terms of pain relief and functional recovery in comparison with arthrodesis. Longer-term follow-up is needed to determine the risks for implant wear and/or degenerative segment changes. Level of Evidence: Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence.

Closed reduction of the cervical spine is a commonly performed method of treatment for acute subluxations or dislocations. Although the recommendation has been debated by many authors3,10, a magnetic resonance image or a myelogram of the cervical spine has been advised for evaluation of lesions occupying the canal before closed reduction in patients who are neurologically intact or who have an incomplete injury of the spinal cord. A sudden or gradual worsening of the neurological status of a patient during reduction should alert the physician to the presence of high-grade compression of the spinal cord. Causes of neurological compression include a spinal epidural hematoma, a herniated intervertebral disc, direct compression of the cord due to osseous fracture fragments, edema of the cord, hemorrhage of the cord, and subdural or subarachnoid hemorrhage13. The prevalence of spinal epidural hematoma associated with fracture of the cervical spine was 4 per cent (two of fifty-two) in the study reported by Wortis and Sharp and 1.7 per cent (six of 357) in that reported by Foo and Rossier. Traumatic causes of spinal epidural hematoma include vertebral fracture-dislocation, birth trauma, lumbar puncture, postoperative bleeding, and missile injury1,4,15-17. Spinal epidural hematoma due to trauma has been reported relatively infrequently in the orthopaedic and neurosurgical literature, and it usually results in progressive neurological deficits that necessitate operative decompression8. We report the case of a patient who had bilateral subluxation of the facet of the fifth cervical vertebra on that of the sixth cervical vertebra. The patient was initially neurologically intact and had a gentle closed reduction with slow extension of the cervical spine. Subsequent acute neurological deterioration indicated the need for urgent acquisition of a magnetic resonance image of the cervical spine, …

We studied the morphology of the thoracic vertebrae in the spines of seventeen human cadavera in order to define parameters that could be used as guidelines for the placement of hooks and screws in the pedicles to obtain internal fixation. We also reviewed computerized tomographic scans of nineteen thoracic spines in living patients who had no evidence of any vertebral deformity. The transverse diameter of the pedicle, which helps to determine the size of the screw, ranged from a mean (and standard deviation) of 4.5 +/- 1.2 millimeters in the fourth thoracic vertebra to a mean of 7.8 +/- 2.0 millimeters in the twelfth thoracic vertebra. The pedicles were inclined anteromedially throughout the thoracic spine, and the angle ranged from 0.3 degree toward the midline in the twelfth thoracic vertebra to 13.9 degrees in the fourth thoracic vertebra. The morphometric data revealed wide variations in the dimensions of the pedicles, demonstrating the importance of accurate preoperative imaging with transaxial computerized tomographic scans to visualize the precise osseous margins and angles of insertion of the thoracic pedicles.

We used computerized tomographic scans and subsequent dissections to evaluate the position of ninety pedicle screws that had been inserted bilaterally into the fourth through twelfth thoracic vertebrae of five fresh-frozen cadavera. The screws had been inserted by five experienced spine surgeons without the use of radiographs or imaging studies. Of the ninety screws, thirty-seven were found to have penetrated the cortex of the pedicle. Twenty-one screws had penetrated the medial cortex and entered the spinal canal, and sixteen had penetrated the lateral cortex. The aorta and the esophagus were at greatest risk for injury after advancement of the screws beyond the anterior vertebral cortex. Computerized tomographic scans of the thoracic spine in nineteen living controls who did not have a spinal abnormality confirmed the proximity of the posterior mediastinal structures to the misplaced screws.

The results for sixty-two patients who had had a diagnosis of diabetes mellitus and lumbar disc disease or spinal stenosis and had been managed with a posterior decompressive procedure were compared, in a retrospective study, with those for sixty-two age and sex-matched non-diabetic (control) patients who had had similar operative procedures. Forty-four of the sixty-two diabetic patients and fifty-five of the non-diabetic patients were available for long-term follow-up (mean, five and seven years, respectively). Among the diabetic patients, there were high rates of postoperative infection and prolonged hospitalization compared with the rates for the control group. The long-term result was excellent or good for seventeen (39 per cent) of the forty-four patients who had diabetes mellitus and for fifty-two (95 per cent) of the fifty-five non-diabetic patients. The poor results in the diabetic patients may have been related to coexisting diabetic neuropathy, to the associated microvascular disease that affects the spinal nerve roots in diabetic patients, or to the failure of the nerve roots of these patients to recover after decompressive procedures.