1. Acute Effects of an Inorganic Phosphorus Additive on Mineral Metabolism and Cardiometabolic Risk Factors in Healthy Subjects
- Author
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Christin Volk, Tabea Kurze, Christof Ulrich, Matthias Girndt, Gabriele I. Stangl, Ulf Schlegelmilch, Corinna Brandsch, Ivo Grosse, and Benjamin Schmidt
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Clinical Biochemistry ,Parathyroid hormone ,chemistry.chemical_element ,Administration, Oral ,Context (language use) ,Biochemistry ,Phosphates ,Hyperphosphatemia ,Young Adult ,Endocrinology ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Cross-Over Studies ,business.industry ,Insulin ,Phosphorus ,Biochemistry (medical) ,Cardiometabolic Risk Factors ,medicine.disease ,Postprandial Period ,Crossover study ,Urinary calcium ,Healthy Volunteers ,Fibroblast Growth Factor-23 ,Postprandial ,chemistry ,Dietary Supplements ,Female ,business - Abstract
Context Hyperphosphatemia and high levels of fibroblast growth factor 23 (FGF23) are risk factors for cardiovascular events in patients with chronic kidney diseases. However, the impact of an inorganic phosphorus additive in healthy people is largely unknown. Objective We aimed to investigate the acute effect of excessive dietary phosphorus administered as sodium dihydrogen phosphate on the postprandial levels of Pi and FGF23 and the response to food. Methods This study was a double-blind placebo-controlled crossover study with 29 healthy male and female participants from the general community who were administered a single dose of either 700 mg phosphorus (NaH2PO4) or a sodium-adjusted placebo in combination with a test meal. Postprandial plasma levels of Pi and FGF23 were measured. Results Compared with placebo, oral phosphorus increased the plasma Pi level, which remained elevated during the ensuing 8 hours (at 480 minutes: 1.31 vs 1.16 mmol/l; P Conclusion An oral phosphorus load can induce elevated postprandial levels of circulating Pi for hours in healthy subjects, despite rapid homeostatic counterreactions. FGF23 levels and the postprandial response to food were not affected.
- Published
- 2021