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Your search keyword '"Kumar, Bhushan"' showing total 27 results
Start Over Author "Kumar, Bhushan" Journal the journal of dermatology
27 results on '"Kumar, Bhushan"'

24. Efficacy and Safety of Cyclosporine versusMethotrexate in Severe Psoriasis: A Study from North India

Author

Sandhu, Kamaldeep, Kaur, Inderjeet, Kumar, Bhushan, and Saraswat, Abir

Abstract

Treatment of patients with severe psoriasis is difficult. Among the number of systemic drugs that are available, methotrexate has long been used, but cyclosporine has been recently recommended for the management of severe psoriasis. The purpose of this study was to compare the efficacy and safety of daily cyclosporine with weekly methotrexate in the management of severe psoriasis. Thirty consecutive patients with severe psoriasis were randomly assigned to treatment with cyclosporine or methotrexate. The initial dose of cyclosporine was 3 mg/kg/day, which was increased to a maximum of 4 mg/kg after two weeks of therapy when the response was not adequate. Methotrexate was administered weekly at a dose of 0.5 mg/kg. Clinical response was assessed by calculating PASI score in all patients at biweekly intervals. Patients were followed up fortnightly up to a maximum of 12 weeks. The doses of both drugs were gradually tapered once >75% reduction in disease severity was attained. Marked improvement (>75%) reduction in PASI was noted in all patients except for one in the cyclosporine group. The median time for marked improvement was 5.3 weeks with methotrexate and 6.8 weeks with cyclosporine. Patients on methotrexate were found to have more rapid and complete clearance than those on cyclosporine. Both drugs were well tolerated. Side effects in both the treatment groups were minor, transient, and manageable. At doses with comparable safety profiles, methotrexate resulted in more rapid and cost effective clearance of patients with severe psoriasis. Cyclosporine can provide an effective and safe alternative.

Published
2003
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25. KID Syndrome: Response to Acitretin

Author

Sahoo, Bijaylaxmi, Handa, Sanjeev, Kaur, Inderjeet, Radotra, Bishan Das, and Kumar, Bhushan

Abstract

KID syndrome is rare. We report a 17‐year‐old girl who presented with universally ichthyotic red hue on the face, trunk, and extremities along with deafness and keratitis since childhood. She was diagnosed with KID syndrome. Treatment with acitretin cleared the hyperkeratotic ichthyotic lesions with little effect on the cornea or hearing. Acitretin seems to be a promising new treatment in KID syndrome.

Published
2002
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27. Zosteriform Pilar Leiomyoma

Author

Sahoo, Bijaylaxmi, Radotra, Bishan Das, Kaur, Inderjeet, and Kumar, Bhushan

Abstract

Pilar leiomyomas are usually multiple and are commonly found on the extensor aspects of the arm, trunk, and face. They are rarely distributed in a linear fashion or seem to follow a dermatome. We report a case of painful, unilateral, zosteriform cutaneous leiomyoma in a 25‐year‐old housewife. Histopathology revealed interlacing smooth muscle bundles arising from arrector pili muscles. Nifedipine (10 mg) twice daily was remarkably effective in diminishing the pain in our patient.

Published
2001
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