1. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines.
- Author
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Moody, M Anthony, Liao, Hua-Xin, Alam, S Munir, Scearce, Richard M, Plonk, M Kelly, Kozink, Daniel M, Drinker, Mark S, Zhang, Ruijun, Xia, Shi-Mao, Sutherland, Laura L, Tomaras, Georgia D, Giles, Ian P, Kappes, John C, Ochsenbauer-Jambor, Christina, Edmonds, Tara G, Soares, Melina, Barbero, Gustavo, Forthal, Donald N, Landucci, Gary, Chang, Connie, King, Steven W, Kavlie, Anita, Denny, Thomas N, Hwang, Kwan-Ki, Chen, Pojen P, Thorpe, Philip E, Montefiori, David C, and Haynes, Barton F
- Subjects
Leukocytes ,Mononuclear ,CD4-Positive T-Lymphocytes ,Monocytes ,Epithelial Cells ,Giant Cells ,Humans ,HIV-1 ,Phosphatidylethanolamines ,Cardiolipins ,Phosphatidylserines ,Complementarity Determining Regions ,Receptors ,CCR5 ,Chemokines ,Chemokines ,CC ,Endotoxins ,Antibodies ,Monoclonal ,Antibodies ,Antiphospholipid ,Culture Media ,Conditioned ,Cell Fusion ,Kinetics ,Mutation ,Immunoglobulin Fab Fragments ,Immunoglobulin Fc Fragments ,beta 2-Glycoprotein I ,Virus Internalization ,env Gene Products ,Human Immunodeficiency Virus ,Chemokine CCL3 ,Chemokine CCL4 ,Immunity ,Innate ,Viral Tropism ,Leukocytes ,Mononuclear ,Receptors ,CCR5 ,CC ,Antibodies ,Monoclonal ,Antiphospholipid ,Culture Media ,Conditioned ,env Gene Products ,Human Immunodeficiency Virus ,Immunity ,Innate ,Immunology ,Medical and Health Sciences - Abstract
Traditional antibody-mediated neutralization of HIV-1 infection is thought to result from the binding of antibodies to virions, thus preventing virus entry. However, antibodies that broadly neutralize HIV-1 are rare and are not induced by current vaccines. We report that four human anti-phospholipid monoclonal antibodies (mAbs) (PGN632, P1, IS4, and CL1) inhibit HIV-1 CCR5-tropic (R5) primary isolate infection of peripheral blood mononuclear cells (PBMCs) with 80% inhibitory concentrations of
- Published
- 2010