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Your search keyword '"Ampel, Neil M."' showing total 11 results
Start Over Author "Ampel, Neil M." Journal the journal of infectious diseases
11 results on '"Ampel, Neil M."'

11. Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} in Cerebrospinal Fluid of Patients with Coccidioidal Meningitis during Therapy with Fluconazole

Author

Ampel, Neil M., Ahmann, Derek R., Delgado, Kathy L., Galgiani, John N., Cloud, Gretchen A., Allergy, the National Institute of, and Group, Infectious Diseases Mycoses Study

Abstract

The levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β in the cerebrospinal fluid (CSF) of 66 patients with coccidioidal meningitis during therapy with fluconazole were measured by ELISA. The median concentration of TNF-α was 15.2 pg/ml, for 322 samples; for IL-1β, it was 4.7 pg/ml, for 316 samples. There were no significant changes in the level of either cytokine over 24 months of follow-up nor was there an association between the initial CSF concentrations of TNF-α and IL-1β and subsequent fluconazole treatment failure. Over time, concentrations of IL-1β were significantly associated with both clinical symptoms and white blood cell counts in CSF. These results indicate that CSF levels of TNF-α and IL-1β are relatively low compared with those associated with acute bacterial meningitis.

Published
1995
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