1. Risk to Nonparticipants in HIV Remission Studies With Treatment Interruption: A Symposium
- Author
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Eyal, Nir and Deeks, Steven G
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Sexually Transmitted Infections ,HIV/AIDS ,Infectious Diseases ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Infection ,Adult ,Aged ,Aged ,80 and over ,Anti-Retroviral Agents ,Biomedical Research ,Duration of Therapy ,Female ,Guidelines as Topic ,HIV Infections ,Humans ,Male ,Middle Aged ,Remission Induction ,Research Design ,Risk Factors ,Sexual Partners ,HIV ,research ethics ,analytic treatment interruption ,HIV cure-related studies ,immunotherapy ,pre-exposure prophylaxis ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Ethical guidelines and recommendations for human subjects research typically focus on protecting the individuals who directly participate in that research. However, additional people, including sex partners of research participants, can also face harms and burdens from medical studies. In human immunodeficiency virus (HIV) cure-related research, a persistent ethical and practical challenge surrounds the use of analytical antiretroviral treatment interruptions. The challenge is usually discussed in relation to risks to study participants, but serious dangers accrue to nonparticipants, including sex partners of study participants. This multidisciplinary supplement relays the risks for nonparticipating sex partners in HIV cure-related studies and addresses the ethical dilemmas raised by these studies, with recommendations for researchers, advocates, sponsors, and oversight bodies.
- Published
- 2019