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Your search keyword '"Nayebare, Patience"' showing total 3 results
Start Over Author "Nayebare, Patience" Journal the journal of infectious diseases
3 results on '"Nayebare, Patience"'

1. Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda

Author

Nankabirwa, Joaniter I, Briggs, Jessica, Rek, John, Arinaitwe, Emmanuel, Nayebare, Patience, Katrak, Shereen, Staedke, Sarah G, Rosenthal, Philip J, Rodriguez-Barraquer, Isabel, Kamya, Moses R, Dorsey, Grant, and Greenhouse, Bryan

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Vector-Borne Diseases, Rare Diseases, HIV/AIDS, Clinical Research, Infectious Diseases, Malaria, 2.4 Surveillance and distribution, Aetiology, Infection, Good Health and Well Being, Adolescent, Adult, Child, Child, Preschool, Disease Reservoirs, Humans, Incidence, Infant, Insecticides, Malaria, Falciparum, Mosquito Control, Mosquito Vectors, Parasitemia, Phenylcarbamates, Prevalence, Uganda, Young Adult, malaria, infectious reservoir, indoor residual spraying, parasitemia, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundIndoor residual spraying of insecticide (IRS) has been associated with reductions in the incidence of malaria, but its impact on malaria parasitemia is unclear.MethodsWe followed 469 participants from August 2011 to May 2016 in Tororo, Uganda, a historically high malaria transmission setting. Three rounds of IRS with bendiocarb were implemented from December 2014 to December 2015. Symptomatic malaria episodes were identified by passive surveillance. Parasitemia was identified by active surveillance every 1-3 months using microscopy and Plasmodium falciparum-specific loop-mediated isothermal amplification.ResultsIRS was associated with a significant decline in the incidence of symptomatic malaria irrespective of age (episodes per person per year declined from 3.98 to 0.13 in children aged

Published
2019

2. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance–Mediating Polymorphisms in Uganda

Author

Conrad, Melissa D, Mota, Daniel, Foster, Marissa, Tukwasibwe, Stephen, Legac, Jennifer, Tumwebaze, Patrick, Whalen, Meghan, Kakuru, Abel, Nayebare, Patience, Wallender, Erika, Havlir, Diane V, Jagannathan, Prasanna, Huang, Liusheng, Aweeka, Francesca, Kamya, Moses R, Dorsey, Grant, and Rosenthal, Philip J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Malaria, Rare Diseases, Infectious Diseases, Genetics, Antimicrobial Resistance, Vector-Borne Diseases, Prevention, 6.1 Pharmaceuticals, 2.1 Biological and endogenous factors, 3.3 Nutrition and chemoprevention, Infection, Good Health and Well Being, Antimalarials, Artemisinins, Drug Combinations, Drug Resistance, Female, Humans, Malaria, Falciparum, Plasmodium falciparum, Polymorphism, Genetic, Pregnancy, Pyrimethamine, Quinolines, Sulfadoxine, P. falciparum, drug resistance, dihydroartemisinin-piperaquine, sulfadoxine-pyrimethamine, IPT, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundIn a recent trial of intermittent preventive treatment in pregnancy (IPTp) in Uganda, dihydroartemisinin-piperaquine (DP) was superior to sulfadoxine-pyrimethamine (SP) in preventing maternal and placental malaria.MethodsWe compared genotypes using sequencing, fluorescent microsphere, and quantitative polymerase chain reaction assays at loci associated with drug resistance in Plasmodium falciparum isolated from subjects receiving DP or SP.ResultsConsidering aminoquinoline resistance, DP was associated with increased prevalences of mutations at pfmdr1 N86Y, pfmdr1 Y184F, and pfcrt K76T compared to SP (64.6% vs 27.4%, P < .001; 93.9% vs 59.2%, P < .001; and 87.7% vs 75.4%, P = .03, respectively). Increasing plasma piperaquine concentration at the time of parasitemia was associated with increasing pfmdr1 86Y prevalence; no infections with the N86 genotype occurred with piperaquine >2.75 ng/mL. pfkelch13 propeller domain polymorphisms previously associated with artemisinin resistance were not identified. Recently identified markers of piperaquine resistance were uncommon and not associated with DP. Considering antifolate resistance, SP was associated with increased prevalence of a 5-mutation haplotype (pfdhfr 51I, 59R, and 108N; pfdhps 437G and 581G) compared to DP (90.8% vs 60.0%, P = .001).ConclusionsIPTp selected for genotypes associated with decreased sensitivity to treatment regimens, but genotypes associated with clinically relevant DP resistance in Asia have not emerged in Uganda.

Published
2017

3. Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda

Author

Nankabirwa, Joaniter I, primary, Briggs, Jessica, additional, Rek, John, additional, Arinaitwe, Emmanuel, additional, Nayebare, Patience, additional, Katrak, Shereen, additional, Staedke, Sarah G, additional, Rosenthal, Philip J, additional, Rodriguez-Barraquer, Isabel, additional, Kamya, Moses R, additional, Dorsey, Grant, additional, and Greenhouse, Bryan, additional

Published
2018
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