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Start Over Author "Vago, Luca" Journal the journal of infectious diseases
7 results on '"Vago, Luca"'

7. Ganciclovir therapy for cytomegalovirus (CMV) infection of the central nervous system in AIDS patients: monitoring by CMV DNA detection in cerebrospinal fluid

Author

Antonella Castagna, Maria Rosa Terreni, Adriano Lazzarin, Flavia Lillo, Milena Furione, Luca Vago, Paola Cinque, Annika Linde, Antonella d'Arminio Monforte, Fausto Baldanti, Cinque, Paola, Baldanti, Fausto, Vago, Luca, Terreni, Maria Rosa, Lillo, Flavia, Furione, Milena, Castagna, Antonella, Monforte, Antonella D’arminio, Lazzarin, Adriano, and Linde, Annika

Subjects
Human cytomegalovirus, Ganciclovir, Congenital cytomegalovirus infection, Biology, medicine.disease_cause, Polymerase Chain Reaction, Herpesviridae, law.invention, law, Betaherpesvirinae, Central Nervous System Diseases, medicine, Immunology and Allergy, Humans, Polymerase chain reaction, Acquired Immunodeficiency Syndrome, virus diseases, medicine.disease, biology.organism_classification, Virology, Real-time polymerase chain reaction, Infectious Diseases, Immunology, Cytomegalovirus Infections, Cytomegalovirus Retinitis, DNA, Viral, Nested polymerase chain reaction, medicine.drug
Abstract

Seven AIDS patients with central nervous system (CNS) disease and cytomegalovirus (CMV) DNA in cerebrospinal fluid (CSF) were evaluated before and 3 weeks after standard ganciclovir treatment by nested polymerase chain reaction (PCR) on limiting dilutions and by quantitative PCR. After therapy, PCR CSF was negative for CMV in 3 patients with low baseline levels of CMV DNA and positive with decreased DNA titers in 4 patients with higher baseline levels. CMV pp65 antigen in polymorphonuclear leukocytes was found in 6 of 7 patients before therapy and in none of 5 after therapy. At autopsy, CMV was found in the CNS of the 4 cases examined, including 3 whose CSF was continuously positive by PCR. Quantitative PCR of CSF is useful for monitoring ganciclovir treatment in CMV infection of the CNS. In AIDS patients, standard ganciclovir treatment seems effective in reducing but not suppressing viral replication in severe cases of CMV infection of the CNS. © 1995 by The University of Chicago.

Published
1995

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