1. Calorie restriction attenuates hypertrophy-induced redox imbalance and mitochondrial ATP-sensitive K
- Author
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Cicera Edna Barbosa, David, Aline Maria Brito, Lucas, Maria Thalyne Silva, Araújo, Beatriz Neves, Coelho, Juarez Braga Soares, Neto, Bruna Raysa Campos, Portela, Anna Lídia Nunes, Varela, Alicia J, Kowaltowski, and Heberty T, Facundo
- Subjects
Male ,Potassium Channels ,Isoproterenol ,Cardiomegaly ,Hydrogen Peroxide ,Antioxidants ,Enzymes ,Mice ,Oxidative Stress ,Glyburide ,Potassium Channel Blockers ,Animals ,Reactive Oxygen Species ,Caloric Restriction - Abstract
Oxidative stress has been implicated in the pathogenesis of cardiac hypertrophy and associated heart failure. Cardiac tissue grows in response to pressure or volume overload, leading to wall thickening or chamber enlargement. If sustained, this condition will lead to a dysfunctional cardiac tissue and oxidative stress. Calorie restriction (CR) is a powerful intervention to improve health and delay aging. Here, we investigated whether calorie restriction in mice prevented isoproterenol-induced cardiac hypertrophy in vivo by avoiding reactive oxygen species (ROS) production and maintaining antioxidant enzymatic activity. Additionally, we investigated the involvement of mitochondrial ATP-sensitive K
- Published
- 2018