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Start Over Author "Stephen B. McNabb" Journal the journal of organic chemistry
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1. Synthesis of macrocyclic beta-strand templates by ring closing metathesis

Author

Andrew D. Abell, Steven G. Aitken, Nathan A. Alexander, James M. Coxon, Stephen B. McNabb, Andrew C. Muscroft-Taylor, Matthew A. Jones, and Hongyuan Chen

Subjects
chemistry.chemical_classification, Ring-closing metathesis, Chemistry, Stereochemistry, Yield (chemistry), Organic Chemistry, X-ray crystallography, Metathesis, Chemical synthesis, Cis–trans isomerism, Cyclic peptide, Acyclic diene metathesis
Abstract

We report the synthesis of macrocycles 1-6 via ring closing metathesis of dienes 7-12. Addition of chlorodicyclohexylborane to thermal and microwave assisted RCM of dienes 8 and 9 markedly improves the yield. The geometric isomers of macrocycles 1-3 and 5 have been assigned using X-ray crystallography and NMR.

Published
2009

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