1. Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration
- Author
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Ellen Rootring, Cheryl L. Sargel, and Joseph D. Tobias
- Subjects
business.industry ,Fistula ,digestive, oral, and skin physiology ,Chronic ingestion ,medicine.disease ,Acetaminophen ,Clinical Vignette ,stomatognathic diseases ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Toxicity ,medicine ,Etiology ,Ingestion ,030211 gastroenterology & hepatology ,Pharmacology (medical) ,Toddler ,Hepatic dysfunction ,business ,medicine.drug - Abstract
Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.
- Published
- 2021
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