1. Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts fromArtemisia annuaL
- Author
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Wonyong Kim, Wan-Su Kim, Dong Chae Lee, Woo Joong Kim, Hyoung-Shik Shin, Sunwoo Lee, Woo Jin Choi, and Uy Dong Sohn
- Subjects
Antioxidant ,Physiology ,medicine.drug_class ,medicine.medical_treatment ,Artemisia annua ,Anti-inflammatory ,Microbiology ,Anti-microbial activity ,Antioxidant activity ,stomatognathic system ,Medicine ,Artemisinin ,Pharmacology ,biology ,Traditional medicine ,business.industry ,Anti-inflammatory effect ,Prevotella intermedia ,Aggregatibacter actinomycetemcomitans ,biology.organism_classification ,Antimicrobial ,stomatognathic diseases ,Original Article ,Fusobacterium nucleatum ,business ,medicine.drug - Abstract
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1β , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0±3.2%), similar to α-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
- Published
- 2014