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3. ANTI-ERYTHROCYTE AUTOIMMUNISATION DURING CHRONIC FALCIPARUM MALARIA

Author

Lefrancois, G., Le Bras, J., Simonneau, M., Bouvet, E., Vroklans, M., and Vachon, F.

Abstract

Anaemia during malaria is not completely understood. Fourteen cases of anti-erythrocyte autoimmunisation with anti-I specificity were investigated in a Paris hospital during a period of 2 years. The patients lived in Gabon and had not been taking antimalarial chemoprophylaxis. All had chronic malaria (strongly positive antimalarial immunofluorescent antibody tests). All the recognised causes for anti-erythrocyte autoimmunity were excluded. One possible explanation for these observations is some sort of interaction between I antigen and Plasmodium,the result of which facilitated penetration of the erythrocyte by the malarial parasite.

Published
1981
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