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Start Over Author "Ross, Paul" Journal the lancet oncology
11 results on '"Ross, Paul"'

1. Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial

Author

Lamarca, Angela, Palmer, Daniel H, Wasan, Harpreet Singh, Ross, Paul J, Ma, Yuk Ting, Arora, Arvind, Falk, Stephen, Gillmore, Roopinder, Wadsley, Jonathan, Patel, Kinnari, Anthoney, Alan, Maraveyas, Anthony, Iveson, Tim, Waters, Justin S, Hobbs, Claire, Barber, Safia, Ryder, W David, Ramage, John, Davies, Linda M, Bridgewater, John A, and Valle, Juan W

Published
2021
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2. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial

Author

Shablack, Alaaeldin, O'Callaghan, Ann, Moody, (Margaret) Anne, Allen, Alex, Brewster, Alison, Brown, Alison, Mayer, Astrid, Davidson, Brian, Ton, Chan, Wilson, Charles, Lowdell, Charles, Rees, Charlotte, Baughan, Christopher, Barlow, Clare, Purcell, Colin, Smith, David, Tsang, David, Brown, Ewan, Walker, Georgina, Malik, Hassan, Cameron, Iain, Nolan, Luke, Hall, Marcia, Tomlinson, Marjorie, Hill, Mark, Peterson, Mark, Finch-Jones, Meg, Kumar, Nagappan, Karanjia, Nariman, Ali, Nasim, Heaton, Nigel, Ton, Nua Chan, Ross, Paul, Praseedom, Raaj, Thomas, Robert, Clive, Sally, Slater, Sarah, Smith, Sarah, Mudan, Satvinder, Bhattacharya, Satya, Essapen, Sharadah, Raouf, Sherif, Fenwick, Stephen, Cleator, Susan, Diamond, Tom, Potter, Vanessa, Bridgewater, John A, Pugh, Siân A, Maishman, Tom, Eminton, Zina, Mellor, Jane, Whitehead, Amy, Stanton, Louise, Radford, Michael, Corkhill, Andrea, Griffiths, Gareth O, Falk, Stephen, Valle, Juan W, O'Reilly, Derek, Siriwardena, Ajith K, Hornbuckle, Joanne, Rees, Myrddin, Iveson, Timothy J, Hickish, Tamas, Garden, O James, Cunningham, David, Maughan, Timothy S, and Primrose, John N

Published
2020
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3. Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study

Author

Primrose, JN, Fox, RP, Morement, H, Chan, O, Rees, C, Ma, YT, Hickish, T, Falk, S, Finch-Jones, M, Pope, I, Corrie, P, Crosby, T, Sothi, S, Sharkland, K, Adamson, D, Wall, L, Evans, J, Dent, J, Hombaiah, U, Iwuji, C, Anthoney, A, Bridgewater, J, Cunningham, D, Gillmore, R, Ross, P, Slater, S, Wasan, H, Waters, J, Valle, JW, Palmer, D, Malik, H, Neoptolemos, J, Faluyi, O, Sumpter, K, Dernedde, U, Maduhusudan, S, Cogill, G, Archer, C, Iveson, T, Wadsley, J, Darby, S, Peterson, M, Mukhtar, AA, Thorpe, JG, Bateman, A, Tsang, D, Cummins, S, Nolan, L, Beaumont, E, Prasad, R, Mirza, D, Stocken, D, Praseedom, R, Davidson, B, Raftery, J, Zhu, S, Garden, J, Stubbs, C, Coxon, F, Primrose, John N, Fox, Richard P, Palmer, Daniel H, Malik, Hassan Z, Prasad, Raj, Mirza, Darius, Anthony, Alan, Corrie, Pippa, Falk, Stephen, Finch-Jones, Meg, Wasan, Harpreet, Ross, Paul, Wall, Lucy, Wadsley, Jonathan, Evans, Jeff T R, Stocken, Deborah, Praseedom, Raaj, Ma, Yuk Ting, Davidson, Brian, Neoptolemos, John P, Iveson, Tim, Raftery, James, Zhu, Shihua, Cunningham, David, Garden, O James, Stubbs, Clive, Valle, Juan W, and Bridgewater, John

Published
2019
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4. Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial

Author

Middleton, Gary, Palmer, Daniel H, Greenhalf, William, Ghaneh, Paula, Jackson, Richard, Cox, Trevor, Evans, Anthony, Shaw, Victoria E, Wadsley, Jonathan, Valle, Juan W, Propper, David, Wasan, Harpreet, Falk, Stephen, Cunningham, David, Coxon, Fareeda, Ross, Paul, Madhusudan, Srinivasan, Wadd, Nick, Corrie, Pippa, Hickish, Tamas, Costello, Eithne, Campbell, Fiona, Rawcliffe, Charlotte, and Neoptolemos, John P

Published
2017
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5. Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

Author

Valle, Juan W, Wasan, Harpreet, Lopes, Andre, Backen, Alison C, Palmer, Daniel H, Morris, Karen, Duggan, Marian, Cunningham, David, Anthoney, D Alan, Corrie, Pippa, Madhusudan, Srinivasan, Maraveyas, Anthony, Ross, Paul J, Waters, Justin S, Steward, Will P, Rees, Charlotte, Beare, Sandy, Dive, Caroline, and Bridgewater, John A

Published
2015
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6. Second-line FOLFOX chemotherapy for advanced biliary tract cancer – Authors' reply

Author

Lamarca, Angela, primary, Palmer, Daniel H, additional, Wasan, Harpreet Singh, additional, Ross, Paul J, additional, Ma, Yuk Ting, additional, Arora, Arvind, additional, Falk, Stephen, additional, Gillmore, Roopinder, additional, Wadsley, Jonathan, additional, Patel, Kinnari, additional, Anthoney, Alan, additional, Maraveyas, Anthony, additional, Iveson, Tim, additional, Waters, Justin S, additional, Hobbs, Claire, additional, Barber, Safia, additional, Ryder, W David, additional, Ramage, John, additional, Davies, Linda M, additional, Bridgewater, John A, additional, and Valle, Juan W, additional

Published
2021
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7. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial

Author

Bridgewater, John A, primary, Pugh, Siân A, additional, Maishman, Tom, additional, Eminton, Zina, additional, Mellor, Jane, additional, Whitehead, Amy, additional, Stanton, Louise, additional, Radford, Michael, additional, Corkhill, Andrea, additional, Griffiths, Gareth O, additional, Falk, Stephen, additional, Valle, Juan W, additional, O'Reilly, Derek, additional, Siriwardena, Ajith K, additional, Hornbuckle, Joanne, additional, Rees, Myrddin, additional, Iveson, Timothy J, additional, Hickish, Tamas, additional, Garden, O James, additional, Cunningham, David, additional, Maughan, Timothy S, additional, Primrose, John N, additional, Shablack, Alaaeldin, additional, O'Callaghan, Ann, additional, Moody, (Margaret) Anne, additional, Allen, Alex, additional, Brewster, Alison, additional, Brown, Alison, additional, Mayer, Astrid, additional, Davidson, Brian, additional, Ton, Chan, additional, Wilson, Charles, additional, Lowdell, Charles, additional, Rees, Charlotte, additional, Baughan, Christopher, additional, Barlow, Clare, additional, Purcell, Colin, additional, Smith, David, additional, Tsang, David, additional, Brown, Ewan, additional, Walker, Georgina, additional, Malik, Hassan, additional, Cameron, Iain, additional, Nolan, Luke, additional, Hall, Marcia, additional, Tomlinson, Marjorie, additional, Hill, Mark, additional, Peterson, Mark, additional, Finch-Jones, Meg, additional, Kumar, Nagappan, additional, Karanjia, Nariman, additional, Ali, Nasim, additional, Heaton, Nigel, additional, Ton, Nua Chan, additional, Ross, Paul, additional, Praseedom, Raaj, additional, Thomas, Robert, additional, Clive, Sally, additional, Slater, Sarah, additional, Smith, Sarah, additional, Mudan, Satvinder, additional, Bhattacharya, Satya, additional, Essapen, Sharadah, additional, Raouf, Sherif, additional, Fenwick, Stephen, additional, Cleator, Susan, additional, Diamond, Tom, additional, and Potter, Vanessa, additional

Published
2020
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8. First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

Author

Wasan, Harpreet S, primary, Gibbs, Peter, additional, Sharma, Navesh K, additional, Taieb, Julien, additional, Heinemann, Volker, additional, Ricke, Jens, additional, Peeters, Marc, additional, Findlay, Michael, additional, Weaver, Andrew, additional, Mills, Jamie, additional, Wilson, Charles, additional, Adams, Richard, additional, Francis, Anne, additional, Moschandreas, Joanna, additional, Virdee, Pradeep S, additional, Dutton, Peter, additional, Love, Sharon, additional, Gebski, Val, additional, Gray, Alastair, additional, van Hazel, Guy, additional, Sharma, Ricky A, additional, Bateman, Andrew, additional, Blesing, Claire, additional, Brown, Ewan, additional, Chau, Ian, additional, Cummins, Sebastian, additional, Cunningham, David, additional, Falk, Stephen, additional, Hadaki, Maher, additional, Hall, Marcia, additional, Hickish, Tamas, additional, Hornbuckle, Joanne, additional, Lofts, Fiona, additional, Lowndes, Sarah, additional, Mayer, Astrid, additional, Metcalfe, Matthew, additional, Middleton, Gary, additional, Montazeri, Amir, additional, Muirhead, Rebecca, additional, Polychronis, Andreas, additional, Purcell, Colin, additional, Ross, Paul, additional, Sherwin, Liz, additional, Smith, David, additional, Soomal, Rubin, additional, Swinson, Daniel, additional, Walther, Axel, additional, Wasan, Harpreet, additional, Wilson, Greg, additional, Amin, Pradip, additional, Angelelli, Bruna, additional, Balosso, Jacques, additional, Beny, Alex, additional, Bloomgarden, Daniel, additional, Boucher, Evelyn, additional, Brown, Michael, additional, Bruch, Harald-Robert, additional, Bui, James, additional, Burge, Matthew, additional, Cardaci, Giuseppe, additional, Carlisle, James, additional, Chai, Seungjean, additional, Chen, Yi-Jen, additional, Chevallier, Patrick, additional, Chuong, Michael, additional, Clarke, Stephen, additional, Coveler, Andrew, additional, Craninx, Michael, additional, Delanoit, Thierry, additional, Deleporte, Amélie, additional, Eliadis, Paul, additional, Facchini, Francis, additional, Ferguson, Thomas, additional, Ferrante, Michel, additional, Frenette, Gary, additional, Frick, Jacob, additional, Ganju, Vinod, additional, Garofalo, Michael, additional, Geboes, Karen, additional, Gehbauer, Gerald, additional, George, Benjamin, additional, Geva, Ravit, additional, Gordon, Michael, additional, Gregory, Kate, additional, Gulec, Seza, additional, Hannigan, James, additional, Heching, Norman, additional, Helmberger, Thomas, additional, Hendlisz, Alain, additional, Hendrickx, Koen, additional, Holtzman, Matthew, additional, Isaacs, Richard, additional, Jackson, Christopher, additional, James, Philip, additional, Kaiser, Adeel, additional, Karapetis, Chris, additional, Kaubisch, Andreas, additional, Ko, Yon-Dschun, additional, Kröning, Hendrik, additional, Lammert, Frank, additional, Liauw, Winston, additional, Limentani, Steven, additional, Louafi, Samy, additional, de Man, Marc, additional, Margolis, Jeffrey, additional, Martin, Robert, additional, Martoni, Andrea, additional, Marx, Gavin, additional, Matos, Marco, additional, Monsaert, Els, additional, Moons, Veerle, additional, Nott, Louise, additional, Nusch, Arnd, additional, O'Donnell, Anne, additional, Ozer, Howard, additional, Padia, Siddarth, additional, Pavlakis, Nick, additional, Perez, David, additional, Pluntke, Stefan, additional, Polus, Marc, additional, Powell, Alex, additional, Pracht, Marc, additional, Price, Timothy, additional, Ransom, David, additional, Rebischung, Christine, additional, Ridwelski, Karsten, additional, Riera-Knorrenschild, Jorge, additional, Riess, Hanno, additional, Rilling, William, additional, Robinson, Bridget, additional, Rodríguez, Javier, additional, Sanchez, Federico, additional, Sauerbruch, Tilmann, additional, Savin, Michael, additional, Scheidhauer, Klemens, additional, Schneiderman, Elyse, additional, Seeger, Grant, additional, Segelov, Eva, additional, Schmueli, Einat Shaham, additional, Shani, Adi, additional, Shannon, Jenny, additional, Sharma, Navesh, additional, Shibata, Stephen, additional, Singhal, Nimit, additional, Smith, Denis, additional, Smith, Randall, additional, Stemmer, Salomon, additional, Stötzer, Oliver, additional, Strickland, Andrew, additional, Tatsch, Klaus, additional, Terrebonne, Eric, additional, Tichler, Thomas, additional, Vehling-Kaiser, Ursula, additional, Vera-Garcia, Ruth, additional, Vogl, Thomas, additional, Walpole, Euan, additional, Wang, Eric, additional, Whiting, Samuel, additional, Wolf, Ido, additional, Ades, Steven, additional, Aghmesheh, Morteza, additional, Auber, Miklos, additional, Ayala, Hubert, additional, Boland, Patrick, additional, Bouche, Eveline, additional, Bowers, Charles, additional, Bremer, Christoph, additional, Burge, Mathew, additional, Casado, Ana Ruiz, additional, Cooray, Prasad, additional, Crain, Martin, additional, De Wit, Maike, additional, Dowling, Kyran, additional, Durand, Aurelie, additional, Faivre, Sandrine, additional, Feeney, Kynan, additional, Ferguson, Tom, additional, Ferru, Aurelie, additional, Fragoso, Maria, additional, Granetto, Cristina, additional, Hammel, Pascal, additional, Issacs, Richard, additional, Iyer, Renuka, additional, Kim, Yeul Hong, additional, Liang, Jin Tung, additional, Lim, Lionel, additional, Liu, Jin Hwang, additional, Masi, Gianluca, additional, Mosconi, Stefania, additional, Numico, Gianmauro, additional, Ratner, Lynn, additional, Sae-Won, Han, additional, Singh, Madhu, additional, Stoltzfus, Patricia, additional, Tan, Iain, additional, Trogu, Antonio, additional, Underhill, Craig, additional, and Westcott, Mark, additional

Published
2017
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9. Guidance on the management of diarrhoea during cancer chemotherapy

Author

Andreyev, Jervoise, primary, Ross, Paul, additional, Donnellan, Clare, additional, Lennan, Elaine, additional, Leonard, Pauline, additional, Waters, Caroline, additional, Wedlake, Linda, additional, Bridgewater, John, additional, Glynne-Jones, Rob, additional, Allum, William, additional, Chau, Ian, additional, Wilson, Richard, additional, and Ferry, David, additional

Published
2014
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10. Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

Author

Middleton, Gary, primary, Silcocks, Paul, additional, Cox, Trevor, additional, Valle, Juan, additional, Wadsley, Jonathan, additional, Propper, David, additional, Coxon, Fareeda, additional, Ross, Paul, additional, Madhusudan, Srinivasan, additional, Roques, Tom, additional, Cunningham, David, additional, Falk, Stephen, additional, Wadd, Nick, additional, Harrison, Mark, additional, Corrie, Pippa, additional, Iveson, Tim, additional, Robinson, Angus, additional, McAdam, Karen, additional, Eatock, Martin, additional, Evans, Jeff, additional, Archer, Caroline, additional, Hickish, Tamas, additional, Garcia-Alonso, Angel, additional, Nicolson, Marianne, additional, Steward, William, additional, Anthoney, Alan, additional, Greenhalf, William, additional, Shaw, Victoria, additional, Costello, Eithne, additional, Naisbitt, Dean, additional, Rawcliffe, Charlotte, additional, Nanson, Gemma, additional, and Neoptolemos, John, additional

Published
2014
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11. Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

Author

Valle, Juan W., Wasan, Harpreet, Lopes, Andre, Backen, Alison C., Palmer, Daniel H., Morris, Karen, Duggan, Marian, Cunningham, David, Anthoney, D. Alan, Corrie, Pippa, Srinivasan, Narayanan, Maraveyas, Anthony, Ross, Paul J., Waters, Justin S., Steward, Will P., Rees, Charlotte, Beare, Sandy, Dive, Caroline, and Bridgewater, John A.

Subjects
Oncology, Articles
Abstract

Summary Background Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of VEGF and its receptors is associated with adverse outcomes. We aimed to assess the effect of the addition of cediranib (an oral inhibitor of VEGF receptor 1, 2, and 3) to cisplatin and gemcitabine on progression-free survival. Methods In this multicentre, placebo-controlled, randomised phase 2 study, we recruited patients aged 18 years or older with histologically confirmed or cytologically confirmed advanced biliary tract cancer from hepatobiliary oncology referral centres in the UK. Patients were eligible if they had an ECOG performance status of 0–1 and an estimated life expectancy of longer than 3 months. Patients were given first-line cisplatin and gemcitabine chemotherapy (25 mg/m2 cisplatin and 1000 mg/m2 gemcitabine [on days 1 and 8 every 21 days, for up to eight cycles]) with either 20 mg oral cediranib or placebo once a day until disease progression. We randomly assigned patients (1:1) with a minimisation algorithm, incorporating the stratification factors: extent of disease, primary disease site, previous treatment, ECOG performance status, and centre. The primary endpoint was progression-free survival in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00939848, and was closed on Sept 30, 2014; results of the final analysis for the primary endpoint are presented. Findings Between April 5, 2011, and Sept 28, 2012, we enrolled 124 patients (62 in each group). With a median follow-up of 12·2 months (IQR 7·3–18·5), median progression-free survival was 8·0 months (95% CI 6·5–9·3) in the cediranib group and 7·4 months (5·7–8·5) in the placebo group (HR 0·93, 80% CI 0·74–1·19, 95% CI 0·65–1·35; p=0·72). Patients who received cediranib had more grade 3–4 toxic effects than did patients who received placebo: hypertension (23 [37%] vs 13 [21%]; p=0·05), diarrhoea (eight [13%] vs two [3%]; p=0·05); platelet count decreased (ten [16%] vs four [6%]; p=0·09), white blood cell decreased (15 [24%] vs seven [11%]; p=0·06) and fatigue (16 [24%] vs seven [11%]; p=0·04). Interpretation Cediranib did not improve the progression-free survival of patients with advanced biliary tract cancer in combination with cisplatin and gemcitabine, which remains the standard of care. Although patients in the cediranib group had more adverse events, we recorded no unexpected toxic effects. The role of VEGF inhibition in addition to chemotherapy for patients with advanced biliary tract cancer remains investigational. Funding Cancer Research UK and AstraZeneca Pharmaceuticals.

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