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Gastric cancer in the United States is characterised by marked racial and ethnic disparities. Widespread declines in Helicobacter pyloriprevalence have contributed to declining gastric cancer incidence. However, H pyloriprevalence shows the same persistent racial and ethnic disparities seen in gastric cancer. The most recent population estimates of H pyloriprevalence in the United States are from the late 1990s and early 2000s and only include three specific racial and ethnic groups. We conducted a scoping review to supplement existing population estimates and assess H pyloriseroprevalence trends over by age and birth cohort with available data. We found the extant data suggest considerable variation in H pyloriprevalence between racial and ethnic groups in the United States and evidence that age and birth cohort trends may differ between groups. We also found that the extant data were limited in generalizability and insufficient to describe trends in many cases.

Gastric cancer persists around the world as one of the leading causes of cancer-related death, despite declines in recent years. The declining prevalence of H pylori, the primary risk factor for gastric cancer, has contributed to this reduction and understanding changes in seroprevalence trends over time may yield further insight into gastric cancer incidence trends. We conducted a scoping review to compile data on H pyloriseroprevalence in asymptomatic populations to assess global trends by age and birth cohort. We found that published data suggest H pyloriseroprevalence declined among recent birth cohorts and increased with age, with trends differing between regions and sub-regions subject to data availability. The Americas lacked sufficient data to enable more robust assessment of H pyloritrends by both age and birth cohort.