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Start Over Author "C. Blyth" Journal the lancet regional health. western pacific
5 results on '"C. Blyth"'

2. Clinical predictors of hypoxic pneumonia in children from the Eastern Highlands Province, Papua New Guinea: secondary analysis of two prospective observational studiesResearch in context

Author

Kathryn J. Britton, William Pomat, Joycelyn Sapura, John Kave, Birunu Nivio, Rebecca Ford, Wendy Kirarock, Hannah C. Moore, Lea-Ann Kirkham, Peter C. Richmond, Jocelyn Chan, Deborah Lehmann, Fiona M. Russell, and Christopher C. Blyth

Subjects
Pneumonia, Child, Hypoxaemia, Clinical signs, Papua New Guinea, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: Pneumonia is the leading cause of death in young children globally and is prevalent in the Papua New Guinea highlands. We investigated clinical predictors of hypoxic pneumonia to inform local treatment guidelines in this resource-limited setting. Methods: Between 2013 and 2020, two consecutive prospective observational studies were undertaken enrolling children 0–4 years presenting with pneumonia to health-care facilities in Goroka Town, Eastern Highlands Province. Logistic regression models were developed to identify clinical predictors of hypoxic pneumonia (oxygen saturation

Published
2024
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3. Effectiveness of 13-valent pneumococcal conjugate vaccine against hypoxic pneumonia and hospitalisation in Eastern Highlands Province, Papua New Guinea: An observational cohort study

Author

Christopher C Blyth, Kathryn J Britton, Cattram D Nguyen, Joycelyn Sapura, John Kave, Birunu Nivio, Jocelyn Chan, Catherine Satzke, Rebecca Ford, Wendy Kirarock, Deborah Lehmann, William Pomat, and Fiona M Russell

Subjects
Psychiatry and Mental health, Infectious Diseases, Health Policy, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health, Internal Medicine, Obstetrics and Gynecology, Geriatrics and Gerontology
Abstract

Pneumonia is a leading cause of childhood mortality withData from two consecutive prospective observational studies (2013-2019) enrolling children60 months presenting with pneumonia were included. Hypoxic pneumonia was defined as oxygen saturations90%. Outcomes included hospitalisation, severe clinical pneumonia and death. 13vPCV status was determined using written records. Logistic regression models were used to estimate the odds ratios of key outcomes by 13vPCV vaccination status adjusted for confounders using inverse probability of treatment weighting.Data from 2067 children (median age; 9 months [IQR: 5-11]) were included. 739 children (36.1%) were hypoxic and 623 (30.4%) hospitalised. Twelve children (0.6% of total cohort) died in hospital. 670 children (32.7%) were fully 13vPCV-vaccinated. 13vPCV vaccination was associated with a 28.7% reduction (95% confidence interval [CI]: 9.9; 43.6%) in hypoxic pneumonia and a 57.4% reduction (38.0; 70.7%) in pneumonia hospitalisation.13vPCV vaccination is effective against hypoxic pneumonia and pneumonia hospitalisation in PNG children. Strategies to improve access to and coverage of 13vPCV in PNG and other similar LMICs are urgently required.Funded by Pfizer Global and the BillMelinda Gates Foundation.

Published
2022

4. Corrigendum to 'Lower risk of multi-system Inflammatory Syndrome in Children (MIS-C) with the Omicron variant' [The Lancet Regional Health - Western Pacific 27 (2022) 100604]

Author

Laura Lopez, David Burgner, Catherine Glover, Jeremy Carr, Julia Clark, Alison Boast, Nan Vasilunas, Brendan McMullan, Joshua R. Francis, Asha C. Bowen, Christopher C. Blyth, Kristine Macartney, Nigel W. Crawford, Emma Carey, Nicholas Wood, and Philip N. Britton

Subjects
Public aspects of medicine, RA1-1270
Published
2023
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