1. Lack of release of platelet factor 4 during exercise-induced myocardial ischemia
- Author
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Herbert Wohl, Sabina R. Wallach, Philip C. Mathis, and Robert L. Engler
- Subjects
Platelet factor ,medicine.medical_specialty ,Myocardial ischemia ,business.industry ,Physical Exertion ,Angiography ,Radioimmunoassay ,Coronary Disease ,General Medicine ,Coronary Angiography ,Platelet Factor 4 ,Blood Coagulation Factors ,Electrocardiography ,In vivo ,Internal medicine ,Cardiology ,Exercise Test ,Medicine ,Humans ,Platelet ,Platelet activation ,business ,Platelet factor 4 - Abstract
PLATELETS have long been implicated as a cause of acute myocardial ischemia,1 2 3 but absolute proof is lacking. Attempts to quantitate in vivo platelet activation during myocardial ischemia have led to the development of a number of indexes of platelet involvement, including the measurement of platelet aggregates4 and of platelet-specific proteins such as β-thromboglobulin and platelet factor 4. However, results have been inconsistent5 , 6 and controversial, and platelets may not be involved in acute myocardial ischemia. Recently, Green and his coworkers presented evidence that patients with coronary-artery disease who are undergoing exercise-stress testing have elevations in platelet factor 4,7 a heparin-neutralizing protein . . .
- Published
- 1981