1. Myeloid-derived suppressor cell and regulatory T cell frequencies in canine myasthenia gravis: A pilot study
- Author
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Oliver A. Garden, Jennifer A. Punt, Ying Wu, Alicia B. Carroll, Evelyn M. Galban, Scott Petesch, Yu-Mei Chang, Neil S. Mittelman, Brandon S. Lawson, Jie Luo, and Leontine Benedicenti
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0301 basic medicine ,Regulatory T cell ,Population ,Cell Count ,Pilot Projects ,T-Lymphocytes, Regulatory ,Article ,Pathogenesis ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Myasthenia Gravis ,Animals ,Medicine ,Dog Diseases ,Longitudinal Studies ,Prospective cohort study ,education ,Autoimmune disease ,education.field_of_study ,General Veterinary ,business.industry ,Myeloid-Derived Suppressor Cells ,Antibody titer ,medicine.disease ,Myasthenia gravis ,030104 developmental biology ,medicine.anatomical_structure ,Immunology ,Myeloid-derived Suppressor Cell ,Animal Science and Zoology ,business ,030215 immunology - Abstract
Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disease. Little is known about its cellular pathogenesis in dogs. This study provides the first preliminary assessment of the frequency of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of dogs with seropositive generalized MG. No alteration in frequency of either MDSCs or Tregs in dogs with MG was observed when compared to those in either seronegative dogs with diagnoses other than MG, or healthy dogs. A longitudinal study in three dogs with MG revealed no correlation between the relative numbers of either population and the clinical course of disease. Neither the frequency of MDSCs nor of Tregs showed a correlation with anti-AChR antibody titer in dogs with MG. These findings suggest that aberrations in the frequency of either immunosuppressive population do not occur in MG, but they need to be validated in large-scale prospective studies.
- Published
- 2021
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