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Your search keyword '"Muyassar Mamtilahun"' showing total 2 results
Start Over Author "Muyassar Mamtilahun" Journal theranostics
2 results on '"Muyassar Mamtilahun"'

1. M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice

Author

Yongfang Li, Ze Liu, Yaying Song, Jia-ji Pan, Yixu Jiang, Xiaojing Shi, Chang Liu, Yuanyuan Ma, Longlong Luo, Muyassar Mamtilahun, Zhiyu Shi, Haroon Khan, Qing Xie, Yongting Wang, Yaohui Tang, Zhijun Zhang, and Guo-Yuan Yang

Subjects
Extracellular Vesicles, Mice, Mice, Inbred ICR, MicroRNAs, Animals, Medicine (miscellaneous), Microglia, Atrophy, White Matter, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Brain Ischemia, Ischemic Stroke
Published
2022
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2. Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion

Author

Rubing Shi, Yuan Zhu, Liping Wang, Jiaji Pan, Zhijun Zhang, Kunlin Jin, Muyassar Mamtilahun, Yongting Wang, Ashwin Venkatesh, Guo-Yuan Yang, Xuanqiang Tu, Lin Yuan Zhang, and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Male, Pathology, medicine.medical_specialty, Medicine (miscellaneous), microglia, Inflammation, Brain Ischemia, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, 03 medical and health sciences, Myelin, Mice, 0302 clinical medicine, medicine, Animals, complement, Complement Pathway, Classical, Receptor, Vascular dementia, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), chronic cerebral hypoperfusion, Neuroinflammation, Mice, Knockout, Microglia, business.industry, Complement C3, medicine.disease, White Matter, Rats, Mice, Inbred C57BL, Perfusion, 030104 developmental biology, medicine.anatomical_structure, Brain Injuries, Knockout mouse, white matter injury, medicine.symptom, business, 030217 neurology & neurosurgery, Research Paper
Abstract

Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement C3-C3aR pathway after chronic cerebral hypoperfusion. Methods: Adult male Sprague-Dawley rats (n = 80) underwent bilateral common carotid artery occlusion for 7, 14, and 28 days. Cerebral vessel density and blood flow were examined by synchrotron radiation angiography and three-dimensional arterial spin labeling. Neurobehavioral assessments, CLARITY imaging, and immunohistochemistry were performed to evaluate activation of microglia and C3-C3aR pathway. Furthermore, C3aR knockout mice were used to establish the causal relationship of C3-C3aR signaling on microglia activation and white matter injury after hypoperfusion. Results: Cerebral vessel density and blood flow were reduced after hypoperfusion (p

Published
2020

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