1. Molecular endoscopic imaging: the future is bright.
- Author
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Ahmed, Shakil, Galle, Peter R., and Neumann, Helmut
- Subjects
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GASTROINTESTINAL disease diagnosis , *CELL receptors , *COLON tumors , *DIAGNOSTIC imaging , *ENDOSCOPY , *EPIDERMAL growth factor , *INFLAMMATORY bowel diseases , *INTERNAL medicine , *MOLECULAR probes , *MOLECULAR diagnosis , *STOMACH tumors , *GASTROINTESTINAL tumors , *VASCULAR endothelial growth factors , *BARRETT'S esophagus , *ENDOSCOPIC gastrointestinal surgery ,RECTUM tumors - Abstract
The prediction and final survival rate of gastrointestinal cancers are dependent on the stage of disease. The ideal would be to detect those gastrointestinal lesions at early stage or even premalignant forms which are difficult to detect by conventional endoscopy with white light optical imaging as they show minimum or no changes in morphological characteristics and are thus left untreated. The introduction of molecular imaging has greatly changed the pattern for detecting gastrointestinal lesions from purely macroscopic structural imaging to the molecular level. It allows microscopic examination of the gastrointestinal mucosa with endoscopy after the topical or systemic application of molecular probes. In recent years, major advancements in endoscopic instruments and specific molecular probes have been achieved. This review focuses on the current status of endoscopic imaging and highlights the application of molecular imaging in gastrointestinal and hepatic disease in the context of diagnosis and therapy based on recently published literature in this field. We also discuss the challenges of molecular endoscopic imaging, its future directions and potential that could have a tremendous impact on endoscopic research and clinical practice in future. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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