1. Effects of Lower Past-Year Serum Sodium and Hyponatremia on Depression Symptoms and Cognitive Impairments in Patients With Hemodialysis.
- Author
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Fan SS, Lin LF, Chen VC, Hsieh CW, Hsiao HP, McIntyre RS, Iacobucci M, Coles AS, Tsai DJ, Weng JC, and Chen YL
- Subjects
- Aged, Female, Humans, Hyponatremia physiopathology, Male, Middle Aged, Renal Insufficiency, Chronic psychology, Renal Insufficiency, Chronic therapy, Retrospective Studies, Surveys and Questionnaires, Cognitive Dysfunction psychology, Depression psychology, Hyponatremia psychology, Renal Dialysis, Sodium blood
- Abstract
The relationship between hyponatremia, depression symptoms, and cognitive impairments in patients receiving hemodialysis treatment remain unclear. This study aimed to examine the impact of past-year average serum sodium levels on current depression symptoms and cognitive impairments in patients receiving hemodialysis, with adjustment for possible confounders. A total of 200 participants were recruited for this study. Depression symptoms and cognitive impairments were assessed using the Patient Health Questionnaire and Perceived Deficits Questionnaire-5, respectively. Additionally, sociodemographic features, physical health, metabolic factors, and substance use information were collected. Significant associations between serum sodium levels, depression symptoms, and cognitive impairments were found after multivariate regression analysis. Furthermore, such differences were observed profoundly in moderate to profound hyponatremia. Our study revealed exclusive relationships between hyponatremia, depression symptoms, and cognitive impairments. As such, programs of cognitive rehabilitation and emotional regulation should be included in the prevention of chronic kidney disease for moderate to profound hyponatremia., (© 2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.)
- Published
- 2020
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