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Combating threats of infectious diseases has been increasingly framed as a global shared responsibility for a multi-actor framework of states, international organisations and nongovernmental actors. However, the outbreak of Ebola Virus Disease (EVD) has shown that this governance framework has not been able to limit the spread of this virus, despite the normative and legislative changes to global disease control. By unbundling the concept of responsibility, this article will assess how global shared responsibility may have failed because accountability does not fall on any one state or stakeholder, highlighting an inherent weakness in the global disease governance regime. The paper concludes that a move towards multiple responsibilities may prove a more effective mechanism for ensuring global health security. [ABSTRACT FROM AUTHOR]