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5 results on '"Casas, Maribel"'

1. Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study.

Author

Koch, Sarah, Peralta, Gabriela Prado, Carsin, Anne-Elie, Abellan, Alicia, Roda, Celine, Torrent, Maties, Iñiguez, Carmen, Ballester, Ferran, Ferrero, Amparo, Zabaleta, Carlos, Lertxundi, Aitana, Guxens, Mònica, Vrijheid, Martine, Sunyer, Jordi, Casas, Maribel, and Garcia-Aymerich, Judith

Subjects
SCIENTIFIC literature, SCIENTIFIC knowledge, HEALTH & Nutrition Examination Survey, DIETARY patterns, JUVENILE diseases, WHEEZE, SEASONAL affective disorder, ECZEMA
Published
2024
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2. Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth

Author

Herrera-Luis, Esther, primary, Mak, Angel C Y, additional, Perez-Garcia, Javier, additional, Martin-Gonzalez, Elena, additional, Eng, Celeste, additional, Beckman, Kenneth B, additional, Huntsman, Scott, additional, Hu, Donglei, additional, González-Pérez, Ruperto, additional, Hernández-Pérez, José M, additional, Mederos-Luis, Elena, additional, Sio, Yang Yie, additional, Poza-Guedes, Paloma, additional, Sardón, Olaia, additional, Corcuera, Paula, additional, Sánchez-Machín, Inmaculada, additional, Korta-Murua, Javier, additional, Martínez-Rivera, Carlos, additional, Mullol, Joaquim, additional, Muñoz, Xavier, additional, Valero, Antonio, additional, Sastre, Joaquin, additional, Garcia-Aymerich, Judith, additional, Llop, Sabrina, additional, Torrent, Maties, additional, Casas, Maribel, additional, Rodríguez-Santana, José R, additional, Villar, Jesús, additional, del Pozo, Victoria, additional, Lorenzo-Diaz, Fabian, additional, Williams, L Keoki, additional, Melén, Erik, additional, Chew, Fook Tim, additional, Borrell, Luisa N, additional, Burchard, Esteban G, additional, and Pino-Yanes, Maria, additional

Published
2022
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3. Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth

Author

Herrera-Luis, Esther, Mak, Angel C Y, Perez-Garcia, Javier, Martin-Gonzalez, Elena, Eng, Celeste, Beckman, Kenneth B, Huntsman, Scott, Hu, Donglei, González-Pérez, Ruperto, Hernández-Pérez, José M, Mederos-Luis, Elena, Sio, Yang Yie, Poza-Guedes, Paloma, Sardón, Olaia, Corcuera, Paula, Sánchez-Machín, Inmaculada, Korta-Murua, Javier, Martínez-Rivera, Carlos, Mullol, Joaquim, Muñoz, Xavier, Valero, Antonio, Sastre, Joaquin, Garcia-Aymerich, Judith, Llop, Sabrina, Torrent, Maties, Casas, Maribel, Rodríguez-Santana, José R, Villar, Jesús, del Pozo, Victoria, Lorenzo-Diaz, Fabian, Williams, L Keoki, Melén, Erik, Chew, Fook Tim, Borrell, Luisa N, Burchard, Esteban G, and Pino-Yanes, Maria

Abstract

BackgroundIn the USA, genetically admixed populations have the highest asthma prevalence and severe asthma exacerbations rates. This could be explained not only by environmental factors but also by genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for severe asthma exacerbations.ObjectiveWe sought to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups by means of admixture mapping analyses and fine mapping, and to assess their transferability to other populations and potential functional roles.MethodsWe performed an admixture mapping in 1124 Puerto Rican and 625 Mexican American children with asthma. Fine-mapping of the significant peaks was performed via allelic testing of common and rare variants. We performed replication across Hispanic/Latino subgroups, and the transferability to non-Hispanic/Latino populations was assessed in 1001 African Americans, 1250 Singaporeans and 941 Europeans with asthma. The effects of the variants on gene expression and DNA methylation from whole blood were also evaluated in participants with asthma and in silico with data obtained through public databases.ResultsGenomewide significant associations of Indigenous American ancestry with severe asthma exacerbations were found at 5q32 in Mexican Americans as well as at 13q13-q13.2 and 3p13 in Puerto Ricans. The single nucleotide polymorphism (SNP) rs1144986 (C5orf46) showed consistent effects for severe asthma exacerbations across Hispanic/Latino subgroups, but it was not validated in non-Hispanics/Latinos. This SNP was associated with DPYSL3DNA methylation and SCGB3A2gene expression levels.ConclusionsAdmixture mapping study of asthma exacerbations revealed a novel locus that exhibited Hispanic/Latino-specific effects and regulated DPYSL3and SCGB3A2.

Published
2023
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