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1. Spirometric patterns in young and middle-aged adults: a 20-year European study

Author

Carsin, Anne-Elie, primary, Garcia-Aymerich, Judith, additional, Accordini, Simone, additional, Dharmage, Shyamali, additional, Leynaert, Bénédicte, additional, de las Heras, Marti, additional, Casas, Lidia, additional, Caviezel, Seraina, additional, Demoly, Pascal, additional, Forsberg, Bertil, additional, Gislason, Thorarinn, additional, Corsico, Angelo Guido, additional, Janson, Christer, additional, Jogi, Rain, additional, Martínez-Moratalla, Jesús, additional, Nowak, Dennis, additional, Gómez, Leopoldo Palacios, additional, Pin, Isabelle, additional, Probst-Hensch, Nicole, additional, Raherison-Semjen, Chantal, additional, Squillacioti, Giulia, additional, Svanes, Cecilie, additional, Torén, Kjell, additional, Urrutia, Isabel, additional, Huerta, Ismael, additional, Anto, Josep Maria, additional, Jarvis, Debbie, additional, and Guerra, Stefano, additional

Published
2023
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2. Spirometric patterns in young and middle-aged adults: a 20-year European study

Author

Carsin, Anne-Elie, Garcia-Aymerich, Judith, Accordini, Simone, Dharmage, Shyamali, Leynaert, Bénédicte, de las Heras, Marti, Casas, Lidia, Caviezel, Seraina, Demoly, Pascal, Forsberg, Bertil, Gislason, Thorarinn, Corsico, Angelo Guido, Janson, Christer, Jogi, Rain, Martínez-Moratalla, Jesús, Nowak, Dennis, Gómez, Leopoldo Palacios, Pin, Isabelle, Probst-Hensch, Nicole, Raherison-Semjen, Chantal, Squillacioti, Giulia, Svanes, Cecilie, Torén, Kjell, Urrutia, Isabel, Huerta, Ismael, Anto, Josep Maria, Jarvis, Debbie, and Guerra, Stefano

Abstract

BackgroundUnderstanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset).MethodsWe used data from the population-based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993–1994) and again 20 years later (ECRHS3, 2010–2013). Spirometry patterns were defined as: restrictive if FEV1/FVC≥LLN and FVC<10th percentile, obstructive if FEV1/FVC

Published
2024
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3. Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS

Author

Moitra, Subhabrata, primary, Carsin, Anne-Elie, additional, Abramson, Michael J, additional, Accordini, Simone, additional, Amaral, Andre F S, additional, Anto, Josep, additional, Bono, Roberto, additional, Casas Ruiz, Lidia, additional, Cerveri, Isa, additional, Chatzi, Leda, additional, Demoly, Pascal, additional, Dorado-Arenas, Sandra, additional, Forsberg, Bertil, additional, Gilliland, Frank, additional, Gislason, Thorarinn, additional, Gullón, Jose A, additional, Heinrich, Joachim, additional, Holm, Mathias, additional, Janson, Christer, additional, Jogi, Rain, additional, Gómez Real, Francisco, additional, Jarvis, Debbie, additional, Leynaert, Bénédicte, additional, Nowak, Dennis, additional, Probst-Hensch, Nicole, additional, Sánchez-Ramos, José Luis, additional, Raherison-Semjen, Chantal, additional, Siroux, Valerie, additional, Guerra, Stefano, additional, Kogevinas, Manolis, additional, and Garcia-Aymerich, Judith, additional

Published
2022
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4. Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS

Author

Moitra, Subhabrata, Carsin, Anne-Elie, Abramson, Michael J, Accordini, Simone, Amaral, Andre F S, Anto, Josep, Bono, Roberto, Casas Ruiz, Lidia, Cerveri, Isa, Chatzi, Leda, Demoly, Pascal, Dorado-Arenas, Sandra, Forsberg, Bertil, Gilliland, Frank, Gislason, Thorarinn, Gullón, Jose A, Heinrich, Joachim, Holm, Mathias, Janson, Christer, Jogi, Rain, Gómez Real, Francisco, Jarvis, Debbie, Leynaert, Bénédicte, Nowak, Dennis, Probst-Hensch, Nicole, Sánchez-Ramos, José Luis, Raherison-Semjen, Chantal, Siroux, Valerie, Guerra, Stefano, Kogevinas, Manolis, and Garcia-Aymerich, Judith

Abstract

IntroductionObesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults.MethodsWe used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index≥30 kg/m2) individuals at visit t. The relative risk (RR) of obesity at t+1associated with asthma at twas estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity.ResultsWe included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II—III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in ≤20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association.ConclusionThis is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids.

Published
2023
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7. Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort

Author

Wang, Gang, primary, Kull, Inger, additional, Bergström, Anna, additional, Hallberg, Jenny, additional, Bergström, Petra Um, additional, Guerra, Stefano, additional, Pershagen, Goran, additional, Gruzieva, Olena, additional, van Hage, Marianne, additional, Georgelis, Antonios, additional, Janson, Christer, additional, Lindén, Anders, additional, and Melén, Erik, additional

Published
2020
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9. Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort.

Author

Gang Wang, Kull, Inger, Bergström, Anna, Hallberg, Jenny, Bergström, Petra Um, Guerra, Stefano, Pershagen, Goran, Gruzieva, Olena, van Hage, Marianne, Georgelis, Antonios, Janson, Christer, Lindén, Anders, Melén, Erik, and Wang, Gang

Subjects
WHEEZE, YOUNG adults, AIR flow, RESEARCH, RESEARCH methodology, RESPIRATORY measurements, WORLD health, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, FORCED expiratory volume, OBSTRUCTIVE lung diseases, DISEASE prevalence, RESEARCH funding, SPIROMETRY
Abstract

We aimed to determine prevalence and early-life risk factors for reversible and irreversible airflow limitation in young adults from the general population. Among young adults in their 20s, the prevalence was 5.3% for reversible airflow limitation and 2.0% for irreversible airflow limitation. While parental asthma was the only risk factor for development of reversible airflow limitation, the risk factors for development of irreversible airflow limitation were current asthma, childhood respiratory tract infections and asthma, and exposure to air pollution. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort

Author

Wang, Gang, Kull, Inger, Bergstro¨m, Anna, Hallberg, Jenny, Bergstro¨m, Petra Um, Guerra, Stefano, Pershagen, Goran, Gruzieva, Olena, van Hage, Marianne, Georgelis, Antonios, Janson, Christer, Lindén, Anders, and Melén, Erik

Abstract

We aimed to determine prevalence and early-life risk factors for reversible and irreversible airflow limitation in young adults from the general population. Among young adults in their 20s, the prevalence was 5.3% for reversible airflow limitation and 2.0% for irreversible airflow limitation. While parental asthma was the only risk factor for development of reversible airflow limitation, the risk factors for development of irreversible airflow limitation were current asthma, childhood respiratory tract infections and asthma, and exposure to air pollution.

Published
2021
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13. sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics.

Author

Hiranrattana, Anunya, Stern, Debra A., Guerra, Stefano, Halonen, Marilyn, Wright, Anne L., Daines, Michael, Martinez, Fernando D., and Morgan, Wayne J.

Subjects
ASTHMA, FUNGAL antigens, FUNGI, OBESITY, RESPIRATORY allergy, SKIN tests, SPIROMETRY, FORCED expiratory volume
Abstract

In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation. [ABSTRACT FROM AUTHOR]

Published
2018
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14. Alternariasensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Author

Hiranrattana, Anunya, Stern, Debra A, Guerra, Stefano, Halonen, Marilyn, Wright, Anne L, Daines, Michael, Martinez, Fernando D, and Morgan, Wayne J

Abstract

In the non-selected birth cohort Tucson Children’s Respiratory Study, early sensitisation to Alternariawas associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternariasensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternariaand AHR among non-asthmatics. Why this group of Alternariasensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

Published
2018
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