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1. Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

Author

Alif, Sheikh M, Dharmage, Shyamali C, Benke, Geza, Dennekamp, Martine, Burgess, John A, Perret, Jennifer L, Lodge, Caroline J, Morrison, Stephen, Johns, David Peter, Giles, Graham G, Gurrin, Lyle C, Thomas, Paul S, Hopper, John Llewelyn, Wood-Baker, Richard, Thompson, Bruce R, Feather, Iain H, Vermeulen, Roel, Kromhout, Hans, Walters, E Haydn, Abramson, Michael J, and Matheson, Melanie Claire

Published
2017
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3. Childhood pneumonia, pleurisy and lung function: a cohort study from the first to sixth decade of life

Author

Perret, Jennifer L, primary, Lodge, Caroline J, additional, Lowe, Adrian J, additional, Johns, David P, additional, Thompson, Bruce R, additional, Bui, Dinh S, additional, Gurrin, Lyle C, additional, Matheson, Melanie C, additional, McDonald, Christine F, additional, Wood-Baker, Richard, additional, Svanes, Cecilie, additional, Thomas, Paul S, additional, Giles, Graham G, additional, Chang, Anne B, additional, Abramson, Michael J, additional, Walters, E Haydn, additional, and Dharmage, Shyamali C, additional

Published
2019
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4. Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

Author

Alif, Sheikh M, Dharmage, Shyamali C, Benke, Geza, Dennekamp, Martine, Burgess, John A, Perret, Jennifer L, Lodge, Caroline J, Morrison, Stephen, Johns, David Peter, Giles, Graham G., Gurrin, Lyle C, Thomas, Paul S, Hopper, John Llewelyn, Wood-Baker, Richard, Thompson, Bruce R, Feather, Iain H, Vermeulen, Roel, Kromhout, Hans, Walters, E Haydn, Abramson, Michael J, Matheson, Melanie Claire, LS IRAS EEPI ME (Milieu epidemiologie), LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), and dIRAS RA-2

Subjects
Pulmonary and Respiratory Medicine, Spirometry, Adult, Male, Chronic bronchitis, Job-exposure matrix, Population, Cumulative Exposure, Tasmania, 03 medical and health sciences, FEV1/FVC ratio, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Risk Factors, Environmental health, Forced Expiratory Volume, Occupational Exposure, Surveys and Questionnaires, Prevalence, Medicine, Humans, 030212 general & internal medicine, Longitudinal Studies, Pesticides, education, COPD, education.field_of_study, medicine.diagnostic_test, business.industry, Smoking, Middle Aged, medicine.disease, respiratory tract diseases, 030228 respiratory system, Relative risk, Female, business, Follow-Up Studies
Abstract

RATIONALE: Population-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occupational exposures are a modifiable risk factor for COPD. OBJECTIVES: To investigate the associations between occupational exposures and fixed airflow obstruction using postbronchodilator spirometry. METHODS: One thousand three hundred and thirty-five participants were included from 2002 to 2008 follow-up of the Tasmanian Longitudinal Health Study (TAHS). Spirometry was performed and lifetime work history calendars were used to collect occupational history. ALOHA plus Job Exposure Matrix was used to assign occupational exposure, and defined as ever exposed and cumulative exposure unit (EU)-years. Fixed airflow obstruction was defined by postbronchodilator FEV1/FVC

Published
2016

5. Childhood pneumonia, pleurisy and lung function: a cohort study from the first to sixth decade of life.

Author

Perret, Jennifer L., Lodge, Caroline J., Lowe, Adrian J., Johns, David P., Thompson, Bruce R., Bui, Dinh S., Gurrin, Lyle C., Matheson, Melanie C., McDonald, Christine F., Wood-Baker, Richard, Svanes, Cecilie, Thomas, Paul S., Giles, Graham G., Chang, Anne B., Abramson, Michael J., Walters, E. Haydn, Dharmage, Shyamali C., and TAHS investigators

Subjects
PLEURISY, LUNGS, PNEUMONIA, COHORT analysis, OBSTRUCTIVE lung diseases, ATOPY, RESEARCH, ASTHMA, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, PULMONARY function tests, QUESTIONNAIRES, LONGITUDINAL method
Abstract

Introduction: Adult spirometry following community-acquired childhood pneumonia has variably been reported as showing obstructive or non-obstructive deficits. We analysed associations between doctor-diagnosed childhood pneumonia/pleurisy and more comprehensive lung function in a middle-aged general population cohort born in 1961.Methods: Data were from the prospective population-based Tasmanian Longitudinal Health Study cohort. Analysed lung function was from ages 7 years (prebronchodilator spirometry only, n=7097), 45 years (postbronchodilator spirometry, carbon monoxide transfer factor and static lung volumes, n=1220) and 53 years (postbronchodilator spirometry and transfer factor, n=2485). Parent-recalled histories of doctor-diagnosed childhood pneumonia and/or pleurisy were recorded at age 7. Multivariable linear and logistic regression were used.Results: At age 7, compared with no episodes, childhood pneumonia/pleurisy-ever was associated with reduced FEV1:FVC for only those with current asthma (beta-coefficient or change in z-score=-0.20 SD, 95% CI -0.38 to -0.02, p=0.028, p interaction=0.036). At age 45, for all participants, childhood pneumonia/pleurisy-ever was associated with a restrictive pattern: OR 3.02 (1.5 to 6.0), p=0.002 for spirometric restriction (FVC less than the lower limit of normal plus FEV1:FVC greater than the lower limit of normal); total lung capacity z-score -0.26 SD (95% CI -0.38 to -0.13), p<0.001; functional residual capacity -0.16 SD (-0.34 to -0.08), p=0.001; and residual volume -0.18 SD (-0.31 to -0.05), p=0.008. Reduced lung volumes were accompanied by increased carbon monoxide transfer coefficient at both time points (z-score +0.29 SD (0.11 to 0.49), p=0.001 and +0.17 SD (0.04 to 0.29), p=0.008, respectively).Discussion: For this community-based population, doctor-diagnosed childhood pneumonia and/or pleurisy were associated with obstructed lung function at age 7 for children who had current asthma symptoms, but with evidence of 'smaller lungs' when in middle age. [ABSTRACT FROM AUTHOR]

Published
2020
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